Work

Epithelioid schwannoma of the chest wall soft tissues mimicking a vascular neoplasm

Year: 2026

Type: article

Abstract: Epithelioid schwannoma is a rare morphological variant of schwannoma that, owing to its unusual histological appearance, may mimic epithelioid neoplasms of various lineages and pose diagnostic challenges. We present a case of a 44-year-old woman with a soft tissue tumor of the chest wall. Histologically, the neoplasm showed a predominantly epithelioid morphology with numerous slit-like and cystic spaces, raising the differential diagnosis of a vascular neoplasm. Immunohistochemically, the tumor demonstrated diffuse expression of S100 and GFAP, with no expression of endothelial, myoepithelial, or melanocytic markers. The diagnosis of epithelioid schwannoma was established based on the combination of morphological features and the immunohistochemical profile. This case highlights the importance of an integrated assessment of morphological and immunohistochemical findings in the diagnosis of epithelioid soft tissue neoplasms.

Source: Oncopathology

DOI: 10.63769/2618-7019-2026-9-3-63-68

Authors: D. A. Maslovskaya, E. I. Kupriyanova, D. A. Murzaeva, I. P. Reznik, V. N. Grinevich

Institutions: Ministry of Health of the Russian Federation, P.A. Hertzen Moscow Oncology Research Institute, Medical Radiological Research Center

Language: English

Topic: Neurofibromatosis and Schwannoma Cases

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7225868948

FWCI:

Cites: 10

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Related to: 10