Expression of EGF and, Ras and Myc Oncogene Products in Normal, Graves' Thyroid, Adenoma, and Carcinoma of the Thyroid
Year: 1989
Type: article
Study design: Observational Study
Abstract: An immunohistochemical study of EGF, and products of ras and myc oncogenes was carried out in 47 cases of non-neoplastic and neoplastic lesions of the thyroid. Normal thyroid tissues showed no significant immunostaining reaction to antibodies for EGF, and products of ras and myc oncogenes. The incidence of EGF positivity was 27%, 46% and 76% in Graves' disease, follicular adenoma, and carcinoma, repectively. The incidence of positivity of ras oncogene product was 27%, 38%, and 82% in Graves' disease, follicular adenoma and carcinoma, respectively. The incidence of positivity of myc oncogene product was 18%, 46% and 71% in Graves' disease, Follicular adenoma, and carcinoma, respectively. These results suggest that EGF, and ras and myc oncogenes or proto-oncogenes play a role in neoplastic lesions of the thyroid.
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W77704492