Experimental Studies on the Relationship between Endocrine Organs and Hypertension in Spontaneously Hypertensive Rats
Year: 1964
Type: article
Abstract: In spontaneously hypertensive rats (Okamoto and Aoki) effects of various hormones on blood pressure of the animals, whose endocrine organ had been removed and which had maintained normotension, were investigated.(1) The administration of ACTH, cortisone or thyroid powder to the animals showing normotension by hypophysectomy increased the blood pressure up to the range of hypertension, but the pressure was lower than that before hypophysectomy. Vasopressin had no such effect on the blood pressure.(2) The administration of cortisone or DCA to the animals showing normotension by adrenalectomy increased the pressure up to the range of hypertension. The administration of thyroid powder slightly raised the blood pressure. Aldosterone and vasopressin had no effect on the blood pressure.(3) The administration of the thyroid powder to the animals showing normotension by thyroidectomy raised the blood pressure up to the range of hypertension. Cortisone and DCA had no effect on the blood pressure.(4) The pituitary hypertensive factors are considered to be ACTH and TSH. The adrenal hypertensive factors are chiefly cortisone-like hormones and the thyroid hypertensive factor is the thyroid hormone.(5) The hypofunction of the thyroid and the adrenals inhibits the development of hypertension and also lowered the hypertension to the normal range. The maintenance of these functions are indispensable for the maintenance of hypertension. Their hyperfunction produces and enhances the hypertension. These functions are presumably controlled by ACTH and TSH from the pituitary.
Source: Japanese Heart Journal
DOI: 10.1536/ihj.5.57
Author: Kyuzo AOKI
Institution: Kyoto University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W954114091