On the Estimation of Survival of HIV/AIDS Patients on Antiretroviral Therapy Using NPMLE Method: An Application to Interval Censored Data
Year: 2013
Type: article
Study design: Observational Study
Abstract: The main objective of this paper is to estimate the survival of HIV/A IDS patients who are undergoing Antiretroviral Therapy in an A RT centre, Delh i. Non Parametric Maximu m Likelihood Estimation NPM LE (E-M ) for interval censoring and KM survival plot for left, right and mid-point imputation have been used to estimate the survival of these patients. It has been observed that the mid-point imputed survival p lot has a very similar and consistent pattern as obtained by NPM LE (E-M ) method. Considering these mid-point imputed value as right censored data, Co x PH model and Accelerated Failure t ime Model (AFTM ) have been applied to identify the effects of prognostic factors like age, sex, mode of transmission, baseline CD4 cell count, hemoglobin, baseline weight and s moking habits on survival o f the patients. The Akaike Info rmation Criterion (AIC) has been employed to compare the efficiency of these models and Co x-Snell residual is used to test the proportionality assumption.
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W96338282