Year: 2008
Type: article
Abstract: The Unfolded Protein Response (UPR) within the Endoplasmic Reticulum (ER) is a quality control mechanism ensuring properly folded proteins.OASIS and XBP-1 are two signal carriers of the UPR.The UPR is linked to tissue and cancer development.Elevated OASIS and XBP-1 activity are observed within developing osteoblasts.Additionally, heightened OASIS activity is present within osteosarcoma while sustained XBP-1 activity, unreported in osteosarcoma, is observed in other cancers.These signaling proteins may mediate development of mature osteoblasts and osteosarcomas.Therefore, evidence is presented with supporting mechanistic hypotheses indicating unique functions for OASIS and XBP-1 in osteoblast differentiation and osteosarcoma.These functions include, but are not limited to, enlarging the ER, buffering unfolded protein accumulation, mitigating UPR-induced cell death, and processing soluble ER proteins destined for secretion.
Author: Aaron Bradford Brister
Institution: Case Western Reserve University
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W96849757