Work

Monocytes and Macrophages

Year: 2000

Type: book-chapter

Abstract: Rheumatoid arthritis (RA) is a disease characterized by an inflammatory response within the joint resulting in cartilage and bone destruction. Infiltration of mononuclear cells, including monocytes and macrophages, in synovial tissues is characteristic of RA. The role of macrophages is essential in the development of a normal inflammatory immune response and host defense. In addition to their functions against infectious agents and tumor cells, and as antigen-presenting cells, macrophages secrete and respond to multiple cytokines and other mediators that control key events in the initiation, resolution, and repair processes of inflammation and the immune response (Table 1). Although macrophages are essential for these events in innate and adaptive host defense, persistent activation of this population may have negative consequences.

Source: Humana Press eBooks

DOI: 10.1007/978-1-59259-018-6_14

Authors: James M. K. Chan, Sharon M. Wahl

Institutions: National Institutes of Health, National Institute of Dental and Craniofacial Research

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W9811571

FWCI:

Cites: 106

Cited by: 5

Related to: 10