Work

Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series

Year: 2015

Type: article

Abstract: A general approach for the synthesis of carbonic anhydrases glycoinhibitors belonging to an aminoxysulfonamide series is presented using a Ferrier sulfonamidoglycosylation reaction on glycals. All the compounds showed good in vitro inhibitory activity against four human carbonic anhydrase isoforms, with selectivity against the cytosolic (hCA II) vs the tumor associated (hCA IX and XII) enzymes.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.5b00175

Authors: Joanna Ombouma, Daniella Vullo, Pascal Dumy, Claudiu T. Supuran, Jean-Yves Winum

Institutions: École Nationale Supérieure de Chimie de Montpellier, Centre National de la Recherche Scientifique, Université de Montpellier, Institut des Biomolécules Max Mousseron, University of Florence

Language: English

Topic: Enzyme function and inhibition

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Centre National de la Recherche Scientifique