OpenAlex | Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects

Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects

Work

Year: 1999

Type: article

Abstract: We have previously demonstrated that genetically based leptin deficiency due to a missense leptin gene mutation in a highly consanguineous extended Turkish pedigree is associated with morbid obesity a... more

Source: The Journal of Clinical Endocrinology & Metabolism

Authors Metin Özata, I. Caglayan Ozdemír, Julio Licinio

Institutions Gülhane Askerî Tıp Akademisi, National Institutes of Health, National Institute of Mental Health

Cites: 50

Cited by: 691

Related to: 10

FWCI: 10.61

Citation percentile (by year/subfield): 95.27

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

Sustainable Development Goal Good health and well-being

Open Access status: bronze