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Author

Sabine Schaertl

Observed names: S Schaertl, S. Schaertl, Schaertl, S.
Institution: Evotec (Germany)
ORCID: 0000-0001-5495-4801
Observed ORCID: 0000-0001-5495-4801
OpenAlex ID: A5002889875
A Profiling Platform for the Characterization of Transglutaminase 2 (TG2) Inhibitors
2010 · Sabine Schaertl, Michael Prime, et al. · SLAS DISCOVERY · 76
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Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease
2012 · Michael E. Prime, Ole A. Andersen, et al. · Journal of Medicinal Chemistry · 70
A Point Mutation of Human Nucleoside Diphosphate Kinase A Found in Aggressive Neuroblastoma Affects Protein Folding
1997 · Ioan Lascu, Sabine Schaertl, et al. · Journal of Biological Chemistry · 65
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Substrate Specificity of Human Nucleoside-diphosphate Kinase Revealed by Transient Kinetic Analysis
1998 · Sabine Schaertl, Manfred Konrad, et al. · Journal of Biological Chemistry · 64
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
2020 · Longbin Liu, Michael E. Prime, et al. · Journal of Medicinal Chemistry · 46
Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors
2011 · Michel C. Maillard, Frederick A. Brookfield, et al. · Bioorganic & Medicinal Chemistry · 40
SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease
2012 · John Wityak, Michael E. Prime, et al. · ACS Medicinal Chemistry Letters · 37
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Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease
2022 · Daniele Bertoglio, Jonathan Bard, et al. · Science Translational Medicine · 34
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A Novel and Robust Homogeneous Fluorescence-Based Assay Using Nanoparticles for Pharmaceutical Screening and Diagnostics
2000 · Sabine Schaertl, Franz-Josef Meyer-Almes, et al. · SLAS DISCOVERY · 32
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
2021 · Frank Herrmann, Manuela Hessmann, et al. · Scientific Reports · 30
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[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins
2021 · Longbin Liu, Peter D. Johnson, et al. · Journal of Medicinal Chemistry · 27
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
2022 · Longbin Liu, Peter D. Johnson, et al. · Journal of Medicinal Chemistry · 24
A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity
2022 · Grit Zahn, Diana M. Willmes, et al. · Metabolites · 22
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Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease
2012 · Michael E. Prime, Frederick A. Brookfield, et al. · ACS Medicinal Chemistry Letters · 21
Human Nucleoside Diphosphate Kinase B (Nm23-H2) from Melanoma Cells Shows Altered Phosphoryl Transfer Activity Due to the S122P Mutation
1999 · Sabine Schaertl, Michael A. Geeves, et al. · Journal of Biological Chemistry · 16
Experiences in Implementing uHTS - Cutting Edge Technology Meets the Real World
2004 · Philip Gribbon, Sabine Schaertl, et al. · Current Drug Discovery Technologies · 12
Quaternary structure of human nucleoside diphosphate kinase isoforms HA and HB in solution
1996 · Sabine Schaertl · FEBS Letters · 10
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Novel MK2 Inhibitors by Fragment Screening
2009 · Oliver Keminer, Joachim Kraemer, et al. · Combinatorial Chemistry & High Throughput Screening · 6
Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin Aggregates
2025 · Longbin Liu, Peter D. Johnson, et al. · Journal of Medicinal Chemistry · 5
Orthosteric inhibition of MutSβ ATPase function: First disclosure of MSH3-bound small molecule inhibitors
2025 · Gareth N. Brace, Karsten Tillack, et al. · Bioorganic & Medicinal Chemistry Letters · 5
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High-Throughput Screening
2014 · Alexander Böcker, Sabine Schaertl, et al. · Royal Society of Chemistry eBooks · 3
A Label-Free LC/MS/MS-Based Enzymatic Activity Assay for the Detection of Genuine Caspase Inhibitors and SAR Development
2013 · Michel C. Maillard, Celia Dominguez, et al. · SLAS DISCOVERY · 3
Nanobeads as a solid phase in a solute homogeneous assay format.
2001 · S Schaertl, F J Meyer-Almes · PubMed · 1
Correction to “Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin Aggregates”
2025 · Longbin Liu, Peter D. Johnson, et al. · Journal of Medicinal Chemistry
E001 Photoaffinity probe-mediated target identification for HTT PET ligand
2024 · Kerstin Danker, Matthew Mills, et al. · Journal of Neurology Neurosurgery & Psychiatry
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Works count: 28
Citation count: 649
H-index: 15
I10-index: 17
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