Author

Mathias Cobbaut

Observed names: Cobbaut Mathias, Cobbaut, Mathias

Institution: The Francis Crick Institute

Observed institutions: The Francis Crick Institute, KU Leuven

ORCID: 0000-0003-0279-0336

Observed ORCID: 0000-0003-0279-0336

OpenAlex ID: A5007258571

Equivocal, explicit and emergent actions of PKC isoforms in cancer

2020 · Peter J. Parker, Sophie J. Brown, et al. · Nature reviews. Cancer · 67

Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease

2020 · Mathias Cobbaut, Simge Karagil, et al. · Cells · 56

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Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms

2018 · Mathias Cobbaut, Johan Van Lint · Oxidative Medicine and Cellular Longevity · 48

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Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling

2017 · Dries Bauters, Mathias Cobbaut, et al. · Molecular Metabolism · 31

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Protein kinase D2: a versatile player in cancer biology

2017 · Ninel Azoitei, Mathias Cobbaut, et al. · Oncogene · 30

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Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors

2020 · Philippe Gilles, Rudra S. Kashyap, et al. · European Journal of Medicinal Chemistry · 22

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Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

2017 · Mathias Cobbaut, Rita Derua, et al. · Scientific Reports · 20

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The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity

2019 · Ahmed Elbediwy, Yixiao Zhang, et al. · Journal of Cell Science · 18

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Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues

2017 · Klaas Verschueren, Mathias Cobbaut, et al. · MedChemComm · 16

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A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

2024 · Sarah E. Conduit, Wayne Pearce, et al. · Nature Communications · 14

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Capture, mutual inhibition and release mechanism for aPKC–Par6 and its multisite polarity substrate Lgl

2025 · Christopher P. Earl, Mathias Cobbaut, et al. · Nature Structural & Molecular Biology · 12

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Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface

2023 · Mathias Cobbaut, Neil Q. McDonald, et al. · Journal of Biological Chemistry · 7

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Protein kinase D displays intrinsic Tyr autophosphorylation activity: insights into mechanism and regulation

2018 · Mathias Cobbaut, Rita Derua, et al. · FEBS Letters · 6

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Genome-Protective Topoisomerase 2a-Dependent G2 Arrest Requires p53 in hTERT-Positive Cancer Cells

2022 · Nicola Lockwood, Silvia Martini, et al. · Cancer Research · 5

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The chordoid glioma PRKCA D463H mutation is a kinase inactive, gain-of-function allele that induces early-onset chondrosarcoma in mice

2025 · Véroniqueo Calleja, Jack C. Henry, et al. · Science Signaling · 2

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Into the fold: advances in understanding aPKC membrane dynamics

2023 · Mathias Cobbaut, Peter J. Parker, et al. · Biochemical Journal · 1

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Lessons in conformational signalling: non-catalytic functions of protein kinase C isozymes

2026 · Angus Cameron, Mathias Cobbaut, et al. · Philosophical Transactions of the Royal Society B Biological Sciences

Data from Genome-Protective Topoisomerase 2a-Dependent G2 Arrest Requires p53 in hTERT-Positive Cancer Cells