Author

Nigel Horscroft

Observed names: Horscroft, Nigel, Horscroft, Nigel John., N Horscroft, N. Horscroft, N. J. Horscroft, Nigel J. Horscroft

Institution: CureVac (Germany)

Observed institutions: University of Veterinary Medicine Vienna, Pfizer (United States), Pfizer (United Kingdom), University of California, Irvine, University of Oxford, Bausch Health (United States), Nabriva Therapeutics (Austria), CureVac (Germany), Orange County Department of Education, Bausch Health (Germany), University of Pennsylvania

ORCID: 0000-0002-7313-2245

Observed ORCID: 0000-0002-7313-2245

OpenAlex ID: A5007498075

An infection-based model of neurodevelopmental damage

1999 · Mady Hornig, Herbert Weissenböck, et al. · Proceedings of the National Academy of Sciences · 265

Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

2017 · Darin K. Edwards, Edith Jasny, et al. · Journal of Translational Medicine · 188

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Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model

2021 · Taihua Yang, Marion Poenisch, et al. · Journal of Hepatology · 174

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mRNA mediates passive vaccination against infectious agents, toxins, and tumors

2017 · Moritz Thran, Jean Mukherjee, et al. · EMBO Molecular Medicine · 173

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Borna Disease Virus Infection of Adult and Neonatal Rats: Models for Neuropsychiatric Disease

2001 · M. Hornig, M. Solbrig, et al. · Current topics in microbiology and immunology · 87

The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691)

2011 · M D Fidock, B E Souberbielle, et al. · Clinical Pharmacology & Therapeutics · 71

Investigating Toll-Like Receptor Agonists for Potential To Treat Hepatitis C Virus Infection

2007 · Amy Thomas, Carl Laxton, et al. · Antimicrobial Agents and Chemotherapy · 67

Antiviral applications of Toll-like receptor agonists

2012 · N. J. Horscroft, D. C. Pryde, et al. · Journal of Antimicrobial Chemotherapy · 60

Mutations in NS5B Polymerase of Hepatitis C Virus: Impacts on in Vitro Enzymatic Activity and Viral RNA Replication in the Subgenomic Replicon Cell Culture

2002 · I.Wayne Cheney, Suhaila Naim, et al. · Virology · 53

Replicon Cell Culture System as a Valuable Tool in Antiviral Drug Discovery against Hepatitis C Virus

2005 · Nigel Horscroft, Vicky CH Lai, et al. · Antiviral chemistry & chemotherapy · 47

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Establishment of a Subgenomic Replicon for Bovine Viral Diarrhea Virus in Huh-7 Cells and Modulation of Interferon-Regulated Factor 3-Mediated Antiviral Response

2005 · Nigel Horscroft, Dan Bellows, et al. · Journal of Virology · 35

Neuroprotection and Reduced Proliferation of Microglia in Ribavirin-Treated Bornavirus-Infected Rats

2002 · Marylou V. Solbrig, Robert Schlaberg, et al. · Antimicrobial Agents and Chemotherapy · 35

Phenylalanine hydroxylase mRNA rescues the phenylketonuria phenotype in mice

2022 · Maximiliano L. Cacicedo, Christine Weinl-Tenbruck, et al. · Frontiers in Bioengineering and Biotechnology · 31

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mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5

2019 · Stefan Hauser, Marion Poenisch, et al. · Molecular Therapy — Methods & Clinical Development · 30

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NTP binding and phosphohydrolase activity associated with purified bluetongue virus non-structural protein NS2

2000 · Nigel J. Horscroft, Polly Roy · Journal of General Virology · 30

Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection

2011 · Thien-Duc Tran, David C. Pryde, et al. · Bioorganic & Medicinal Chemistry Letters · 29

Therapy with TLR7 Agonists Induces Lymphopenia: Correlating Pharmacology to Mechanism in a Mouse Model

2012 · Hannah Perkins, Tansi Khodai, et al. · Journal of Clinical Immunology · 28

Neurotrophic Factor Expression After CNS Viral Injury Produces Enhanced Sensitivity to Psychostimulants: Potential Mechanism for Addiction Vulnerability

2000 · Marylou V. Solbrig, George F. Koob, et al. · Journal of Neuroscience · 26

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Discovery of a highly potent series of TLR7 agonists

2011 · Peter Jones, David C. Pryde, et al. · Bioorganic & Medicinal Chemistry Letters · 21

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

2010 · David C. Pryde, Thien-Duc Tran, et al. · MedChemComm · 19

mRNA-based therapy proves superior to the standard of care for treating hereditary tyrosinemia 1 in a mouse model

2022 · Maximiliano L. Cacicedo, Christine Weinl-Tenbruck, et al. · Molecular Therapy — Methods & Clinical Development · 15

Knockdown of USP18 Increases Alpha 2a Interferon Signaling and Induction of Interferon-Stimulating Genes but Does Not Increase Antiviral Activity in Huh7 Cells

2011 · E. J. Murray, Frances Burden, et al. · Antimicrobial Agents and Chemotherapy · 15

Thermal Denaturation of Proteins for SDS-PAGE Analysis by Microwave Irradiation

1997 · Nigel J. Horscroft, Polly Roy · BioTechniques · 12

Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies

2023 · Moritz Thran, Marion Pönisch, et al. · Scientific Reports · 11

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A Nine-Strain Bacterial Consortium Improves Portal Hypertension and Insulin Signaling and Delays NAFLD Progression In Vivo

2022 · Iris Pinheiro, Aurora Barberá, et al. · Biomedicines · 8

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Works count: 39

Citation count: 1,547

H-index: 19

I10-index: 24