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Michael E. Prime

Observed names: M. E. PRIME, M. Prime, M.E. Prime, Michael E Prime, Michael Prime, Prime, M.E.
ORCID: 0000-0002-5744-6885
Observed ORCID: 0000-0002-5744-6885
OpenAlex ID: A5008600756
Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase
2010 · Michael E. Prime, Stephen M. Courtney, et al. · Journal of Medicinal Chemistry · 86
A Profiling Platform for the Characterization of Transglutaminase 2 (TG2) Inhibitors
2010 · Sabine Schaertl, Michael Prime, et al. · SLAS DISCOVERY · 76
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Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease
2012 · Michael E. Prime, Ole A. Andersen, et al. · Journal of Medicinal Chemistry · 71
Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease
2015 · Leticia M. Toledo-Sherman, Michael E. Prime, et al. · Journal of Medicinal Chemistry · 67
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
2020 · Longbin Liu, Michael E. Prime, et al. · Journal of Medicinal Chemistry · 46
Metabolism and Pharmacokinetics of JM6 in Mice: JM6 Is Not a Prodrug for Ro-61-8048
2012 · Maria G. Beconi, Dawn Yates, et al. · Drug Metabolism and Disposition · 39
SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease
2012 · John Wityak, Michael E. Prime, et al. · ACS Medicinal Chemistry Letters · 37
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A Novel Route to Preussomerins via 2-Arylacetal Anions
2000 · Jacques P. Ragot, Michael E. Prime, et al. · Organic Letters · 37
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease
2022 · Daniele Bertoglio, Jonathan Bard, et al. · Science Translational Medicine · 34
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Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
2021 · Frank Herrmann, Manuela Hessmann, et al. · Scientific Reports · 30
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A versatile, non-biomimetic route to the preussomerins: syntheses of (±)-preussomerins F, K and L
2004 · Ernesto Quesada, Martin Stockley, et al. · Organic & Biomolecular Chemistry · 29
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[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins
2021 · Longbin Liu, Peter D. Johnson, et al. · Journal of Medicinal Chemistry · 27
Concise Syntheses of γ-Oxo-β,β-difluorinated Amino Acids via Chelated [3,3]-Rearrangement of Difluoroallylic Alcohols
1998 · Jonathan M. Percy, Michael E. Prime, et al. · The Journal of Organic Chemistry · 27
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
2022 · Longbin Liu, Peter D. Johnson, et al. · Journal of Medicinal Chemistry · 24
Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease
2012 · Michael E. Prime, Frederick A. Brookfield, et al. · ACS Medicinal Chemistry Letters · 21
Synthesis of α-hydroxy-β,β-difluoro-γ-ketoesters via [3,3]sigmatropic rearrangements
2000 · Michael J. Broadhurst, Samantha J. Brown, et al. · Journal of the Chemical Society Perkin Transactions 1 · 21
Rearrangement routes to selectively fluorinated compounds
1999 · Jonathan M. Percy, Michael E. Prime · Journal of Fluorine Chemistry · 18
Chelated [3,3]-rearrangements of difluoroallylic alcohols
1997 · M.J. Broadhurst, J.M. Percy, et al. · Tetrahedron Letters · 17
Development of LC/MS/MS, High-Throughput Enzymatic and Cellular Assays for the Characterization of Compounds That Inhibit Kynurenine Monooxygenase (KMO)
2013 · Dirk Winkler, Maria Beconi, et al. · SLAS DISCOVERY · 15
Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin Aggregates
2025 · Longbin Liu, Peter D. Johnson, et al. · Journal of Medicinal Chemistry · 5
A06 Chdi-00340246, A Kynurenine Monooxygenase Inhibitor As Potential Therapeutic Agent For The Treatment Of Huntington's Disease
2014 · L. Toledo-Sherman, M. Prime, et al. · Journal of Neurology Neurosurgery & Psychiatry · 1
Correction to “Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin Aggregates”
2025 · Longbin Liu, Peter D. Johnson, et al. · Journal of Medicinal Chemistry
Prodrug for Ro-61-8048
2012 · Maria Beconi, Dawn Yates, et al.
A Versatile, Non‐Biomimetic Route to the Preussomerins: Syntheses of (.+‐.)‐Preussomerins F, K and L.
2005 · Ernesto Quesada, Martin Stockley, et al. · ChemInform
CCDC 239166: Experimental Crystal Structure Determination
2005 · Quesada, E., Stockley, M., et al. · The Cambridge Structural Database
Works count: 31
Citation count: 728
H-index: 17
I10-index: 19
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