Get started
Author

Mark J. Gemkow

Observed name: M. Gemkow
Institution: Evotec (Germany)
Observed institution: Evotec (Germany)
OpenAlex ID: A5010043658
The histamine H3 receptor as a therapeutic drug target for CNS disorders
2009 · Mark J. Gemkow, Adam J. Davenport, et al. · Drug Discovery Today · 183
Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers
2021 · Adam J. Davenport, Ioana Neagoe, et al. · Scientific Reports · 70
PDF
An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction
2010 · Stephen P. East, Samantha Bamford, et al. · Bioorganic & Medicinal Chemistry Letters · 47
Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors
2011 · Michel C. Maillard, Frederick A. Brookfield, et al. · Bioorganic & Medicinal Chemistry · 40
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity
2008 · Monika Ermann, Doris Riether, et al. · Bioorganic & Medicinal Chemistry Letters · 30
1,4-Diazepane compounds as potent and selective CB2 agonists: Optimization of metabolic stability
2011 · Doris Riether, Lifen Wu, et al. · Bioorganic & Medicinal Chemistry Letters · 21
Selective CB2 receptor agonists. Part 1: The identification of novel ligands through computer-aided drug design (CADD) approaches
2014 · Eugene R. Hickey, Renee Zindell, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Morpholine containing CB2 selective agonists
2009 · Renée Zindell, Doris Riether, et al. · Bioorganic & Medicinal Chemistry Letters · 19
Using Electrophysiology and In Silico Three-Dimensional Modeling to Reduce Human Ether-à-go-go Related Gene K + Channel Inhibition in a Histamine H3 Receptor Antagonist Program
2010 · Adam J. Davenport, Clemens Möller, et al. · Assay and Drug Development Technologies · 16
Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: Optimization of drug-like properties and target independent parameters
2011 · Renée Zindell, Edward R. Walker, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Selective CB2 receptor agonists. Part 3: The optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model
2014 · Alessandra Bartolozzi, Pier Francesco Cirillo, et al. · Bioorganic & Medicinal Chemistry Letters · 14
Selective CB2 receptor agonists. Part 2: Structure–activity relationship studies and optimization of proline-based compounds
2014 · Doris Riether, Renee Zindell, et al. · Bioorganic & Medicinal Chemistry Letters · 14
Discovery of substituted benzyl tetrazoles as histamine H3 receptor antagonists
2010 · Adam J. Davenport, Christopher C. Stimson, et al. · Bioorganic & Medicinal Chemistry Letters · 8
A Label-Free LC/MS/MS-Based Enzymatic Activity Assay for the Detection of Genuine Caspase Inhibitors and SAR Development
2013 · Michel C. Maillard, Celia Dominguez, et al. · SLAS DISCOVERY · 3
M20 Activation Of The Trkb Receptor Pathway Using A Novel Monoclonal Antibody Agonist: Implications For The Treatment Of Huntington's Disease
2014 · N. Carty, L. Schmidt, et al. · Journal of Neurology Neurosurgery & Psychiatry · 1
Works count: 15
Citation count: 501
H-index: 12
I10-index: 12
Year
Topic
Type