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Luke A. Masterson
Observed names:
Luke A Masterson,
Luke Masterson
Observed institutions:
AstraZeneca (United Kingdom),
University of London,
University of Nottingham,
University of Strathclyde,
University of Cambridge,
Cancer Research UK,
Spirogen (United Kingdom),
UCL School of Pharmacy,
University College London,
Cardiff University
show all 10
ORCID:
0000-0002-5366-4025
Observed ORCID:
0000-0002-5366-4025
OpenAlex ID:
A5044830291
A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology
2013
·
Scott C. Jeffrey
, Patrick J. Burke
, et al.
·
Bioconjugate Chemistry
·
247
Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload
2016
·
Arnaud C. Tiberghien
, Jean-Noel Levy
, et al.
·
ACS Medicinal Chemistry Letters
·
166
Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody–Drug Conjugates Using Click Cycloaddition Chemistry
2015
·
Michael P. VanBrunt
, Kurt Shanebeck
, et al.
·
Bioconjugate Chemistry
·
149
Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
2018
·
John A. Hartley
, Michael J. Flynn
, et al.
·
Scientific Reports
·
134
PDF
ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies
2016
·
Michael J. Flynn
, Francesca Zammarchi
, et al.
·
Molecular Cancer Therapeutics
·
128
Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity
2017
·
BinQing Wei
, Janet Gunzner-Toste
, et al.
·
Journal of Medicinal Chemistry
·
113
SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads
2018
·
Krista Kinneer
, John Meekin
, et al.
·
Clinical Cancer Research
·
99
Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates
2006
·
Geoff Wells
, Christopher R. H. Martin
, et al.
·
Journal of Medicinal Chemistry
·
80
Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305
2022
·
Krista Kinneer
, Philipp Wortmann
, et al.
·
Clinical Cancer Research
·
74
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers
2017
·
Thomas H. Pillow
, Melissa Schutten
, et al.
·
Molecular Cancer Therapeutics
·
73
Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads
2018
·
Amit Kumar
, Krista Kinneer
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
72
SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity
2010
·
John A. Hartley
, Anzu Hamaguchi
, et al.
·
Cancer Research
·
61
PDF
Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus
2020
·
Kate M. Moore
, Ami Desai
, et al.
·
Theranostics
·
50
PDF
Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates
2017
·
Mary Jane Masson Hinrichs
, Pauline M. Ryan
, et al.
·
Clinical Cancer Research
·
48
Straightforward Glycoengineering Approach to Site-Specific Antibody–Pyrrolobenzodiazepine Conjugates
2016
·
Pamela Thompson
, Ebele Ezeadi
, et al.
·
ACS Medicinal Chemistry Letters
·
41
Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers
2017
·
Stephen J. Gregson
, Luke A. Masterson
, et al.
·
Journal of Medicinal Chemistry
·
37
Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate
2009
·
Philip W. Howard
, Zhizhi Chen
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
33
Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR
2021
·
Shenlan Mao
, Raghothama Chaerkady
, et al.
·
Molecular Cancer Therapeutics
·
32
Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers
2019
·
Stephen J. Gregson
, Allison M. Barrett
, et al.
·
European Journal of Medicinal Chemistry
·
26
Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates
2004
·
Luke A. Masterson
, Stephen J. Croker
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
26
Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer
2019
·
Jason B. White
, Ryan Fleming
, et al.
·
mAbs
·
24
PDF
Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy
2005
·
Luke A. Masterson
, Victoria J. Spanswick
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
24
Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying Its Stability In Vivo
2024
·
Yue Huang
, Hui Yin Tan
, et al.
·
Analytical Chemistry
·
14
PDF
Integrin-αvβ6 targeted peptide-toxin therapy in a novel αvβ6-expressing immunocompetent model of pancreatic cancer
2024
·
Nicholas F. Brown
, Elizabeth R. Murray
, et al.
·
Pancreatology
·
13
Engineered Ultrasmall Nanoparticle Drug‐Immune Conjugates with “Hit and Run” Tumor Delivery to Eradicate Gastric Cancer
2022
·
Li Zhang
, Virginia Aragon‐Sanabria
, et al.
·
Advanced Therapeutics
·
11
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Works count:
94
Citation count:
1,879
H-index:
22
I10-index:
31
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