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Frank Totzke

Observed names: F Totzke, F. Totzke, Frank TOTZKE, Totzke, Frank
Observed institutions: University of Vienna, University of Freiburg, German Cancer Research Center, University of Strathclyde, Johannes Gutenberg University Mainz, University of Würzburg, University of Perugia, A N Bach Institute of Biochemistry, Russian Cancer Research Center NN Blokhin, Institut de Science et d'Ingénierie Supramoléculaires, University Medical Center Hamburg-Eppendorf, Gause Institute of New Antibiotics Russian Academy of Medical Sciences, Reaction Biology (Germany), Helmholtz Centre for Infection Research, Vavilov Institute of General Genetics, Pepscan (Netherlands), Institut für Chirurgische Forschung, Heinrich Heine University Düsseldorf, Martin Luther University Halle-Wittenberg, Palacký University Olomouc, University of Tübingen, Ludwig-Maximilians-Universität München, Technische Universität Braunschweig
ORCID: 0000-0002-7261-8155
Observed ORCID: 0000-0002-7261-8155
OpenAlex ID: A5047208370
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.
2000 · J M Wood, G Bold, et al. · PubMed · 845
Roscovitine Targets, Protein Kinases and Pyridoxal Kinase
2005 · Stéphane Bach, Marie Knockaert, et al. · Journal of Biological Chemistry · 368
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Cytotoxic Metabolites from the Fungal Endophyte Alternaria sp. and Their Subsequent Detection in Its Host Plant Polygonum senegalense
2008 · Amal H. Aly, RuAngelie Edrada-Ebel, et al. · Journal of Natural Products · 262
Mapping of the Sites for Ligand Binding and Receptor Dimerization at the Extracellular Domain of the Vascular Endothelial Growth Factor Receptor FLT-1
1997 · Bernhard Barleon, Frank Totzke, et al. · Journal of Biological Chemistry · 196
Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum Isolated from Mentha pulegium
2009 · Abdessamad Debbab, Amal H. Aly, et al. · Journal of Natural Products · 166
Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors
2013 · Maria Letícia de Castro Barbosa, Lídia Moreira Lima, et al. · European Journal of Medicinal Chemistry · 150
Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation
2008 · Wim Wätjen, Abdessamad Debbab, et al. · Molecular Nutrition & Food Research · 119
Design, Synthesis, and Biological Evaluation of 3,4-Diarylmaleimides as Angiogenesis Inhibitors
2006 · Christian Peifer, Thomas Stoiber, et al. · Journal of Medicinal Chemistry · 111
Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors
2001 · Bernhard Barleon, Petra Reusch, et al. · Angiogenesis · 111
7-Bromoindirubin-3′-oxime induces caspase-independent cell death
2006 · J Ribas, K Bettayeb, et al. · Oncogene · 106
Design, Synthesis, and Biological Evaluation of Novel 3-Aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as Vascular Endothelial Growth Factor Receptor (VEGF-R) Inhibitors
2008 · Christian Peifer, Roland Selig, et al. · Journal of Medicinal Chemistry · 95
Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors
2012 · Claas Hundsdörfer, Hans-Jörg Hemmerling, et al. · Bioorganic & Medicinal Chemistry · 93
Inverse In Silico Screening for Identification of Kinase Inhibitor Targets
2007 · Stefan Zahler, Simon Tietze, et al. · Chemistry & Biology · 86
Anthraquinones and Betaenone Derivatives from the Sponge-Associated Fungus Microsphaeropsis Species: Novel Inhibitors of Protein Kinases
2000 · Gernot Brauers, Ru Angelie Edrada, et al. · Journal of Natural Products · 82
Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors
2007 · Pierre‐Yves Dakas, Sofia Barluenga, et al. · Angewandte Chemie International Edition · 78
Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases
2011 · Bassam Abu Thaher, Martina Arnsmann, et al. · Journal of Medicinal Chemistry · 75
Arthrinins A–D: Novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
2011 · Sherif S. Ebada, Barbara Schulz, et al. · Bioorganic & Medicinal Chemistry · 73
Identification of 2-Anilino-9-methoxy-5,7-dihydro-6 H -pyrimido[5,4- d ][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead Generation
2010 · Anne-Marie Egert-Schmidt, Jan Dreher, et al. · Journal of Medicinal Chemistry · 72
Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9
2010 · Ulrike K. Schmerwitz, Gabriele Sass, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 61
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Decalactone Derivatives from Corynespora cassiicola, an Endophytic Fungus of the Mangrove Plant Laguncularia racemosa
2012 · Weaam Ebrahim, Amal H. Aly, et al. · European Journal of Organic Chemistry · 55
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Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells
2013 · Christian Limper, Yao Wang, et al. · Journal of Pharmacy and Pharmacology · 52
2-Anilino-4-(benzimidazol-2-yl)pyrimidines – A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines
2012 · Renate Determann, Jan Dreher, et al. · European Journal of Medicinal Chemistry · 51
Structure‐Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone
2005 · Conrad Kunick, Zhihong Zeng, et al. · ChemBioChem · 45
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes
2004 · Burkhardt Voigt, Laurent Meijer, et al. · Bioorganic & Medicinal Chemistry Letters · 45
The Drosophila melanogaster l(2)gl gene encodes a protein homologous to the cadherin cell-adhesion molecule family
1989 · Christian Klämbt, Stephan Müller, et al. · Developmental Biology · 45
Works count: 99
Citation count: 4,353
H-index: 32
I10-index: 57
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