Author

Carleton R. Sage

Observed names: C. R. Sage, C.R. Sage, Carleton R Sage, Carleton Sage, Sage, C.

Observed institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), North Carolina State University, University of California, Santa Barbara, University of California, San Francisco, Arena Pharmaceuticals (United States), Eurofins (United States)

ORCID: 0009-0008-6270-1861

Observed ORCID: 0009-0008-6270-1861

OpenAlex ID: A5061236885

3-(1 H -Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice

2008 · Graeme Semple, Philip J. Skinner, et al. · Journal of Medicinal Chemistry · 104

1-Alkyl-benzotriazole-5-carboxylic Acids Are Highly Selective Agonists of the Human Orphan G-Protein-Coupled Receptor GPR109b

2006 · Graeme Semple, Philip J. Skinner, et al. · Journal of Medicinal Chemistry · 80

The additivity of substrate fragments in enzyme–ligand binding

1998 · Thomas J Stout, Carleton R Sage, et al. · Structure · 78

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Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor

2014 · Daniel J. Buzard, Sun Hee Kim, et al. · ACS Medicinal Chemistry Letters · 76

Microtubule Dynamics Modulated by Guanosine Triphosphate Hydrolysis Activity of β-Tubulin

1994 · Ashley Davis, Carleton R. Sage, et al. · Science · 70

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

2011 · Graeme Semple, Albert Ren, et al. · Bioorganic & Medicinal Chemistry Letters · 68

Purification and biochemical characterization of tubulin from the budding yeast Saccharomyces cerevisiae

1993 · Ashley Davis, Carleton R. Sage, et al. · Biochemistry · 65

Molecular Hashkeys: A Novel Method for Molecular Characterization and Its Application for Predicting Important Pharmaceutical Properties of Molecules

1999 · Anwar M. Ghuloum, Carleton R. Sage, et al. · Journal of Medicinal Chemistry · 62

(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans

2012 · P. Douglas Boatman, Brett Lauring, et al. · Journal of Medicinal Chemistry · 54

Analogues of Acifran: Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b

2007 · Jae-Kyu Jung, Benjamin R. Johnson, et al. · Journal of Medicinal Chemistry · 54

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

2011 · Graeme Semple, Juerg Lehmann, et al. · Bioorganic & Medicinal Chemistry Letters · 52

GPCRs: an update on structural approaches to drug discovery

2003 · Nigel R.A. Beeley, Carleton Sage · TARGETS · 35

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

2010 · P. Douglas Boatman, Thomas O. Schrader, et al. · Bioorganic & Medicinal Chemistry Letters · 34

A new family of H3 receptor antagonists based on the natural product Conessine

2007 · Vincent J. Santora, Jonathan A. Covel, et al. · Bioorganic & Medicinal Chemistry Letters · 32

Agonist lead identification for the high affinity niacin receptor GPR109a

2007 · Tawfik Gharbaoui, Philip J. Skinner, et al. · Bioorganic & Medicinal Chemistry Letters · 31

D221 in Thymidylate Synthase Controls Conformation Change, and Thereby Opening of the Imidazolidine,

1998 · Carleton R. Sage, Melissa D. Michelitsch, et al. · Biochemistry · 31

3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b

2007 · Philip J. Skinner, Martin C. Cherrier, et al. · Bioorganic & Medicinal Chemistry Letters · 30

Mutation in the β-Tubulin Signature Motif Suppresses Microtubule GTPase Activity and Dynamics, and Slows Mitosis

2001 · Cynthia A. Dougherty, Carleton R. Sage, et al. · Biochemistry · 29

An Essential Role for Water in an Enzyme Reaction Mechanism: The Crystal Structure of the Thymidylate Synthase Mutant E58Q,

1996 · Carleton R. Sage, Earl E. Rutenber, et al. · Biochemistry · 26

β‐Tubulin mutation suppresses microtubule dynamics in vitro and slows mitosis in vivo

1995 · Carleton R. Sage, Ashley S. Davis, et al. · Cell Motility and the Cytoskeleton · 26

5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b

2009 · Philip J. Skinner, Peter J. Webb, et al. · Bioorganic & Medicinal Chemistry Letters · 25

Site-Directed Mutagenesis of Putative GTP-Binding Sites of Yeast .beta.-Tubulin: Evidence That .alpha.-, .beta.-, and .gamma.-Tubulins Are Atypical GTPases

1995 · Carleton R. Sage, Cynthia A. Dougherty, et al. · Biochemistry · 25

Intronic U14 snoRNAs ofXenopus laevisare located in two different parent genes and can be processed from their introns during early oogenesis

1995 · Ling Xia, Joyce Liu, et al. · Nucleic Acids Research · 24

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Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension

2017 · Thuy-Anh Tran, Bryan Kramer, et al. · Journal of Medicinal Chemistry · 20

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Investigating interactions between phentermine, dexfenfluramine, and 5-HT2C agonists, on food intake in the rat

2014 · Andrew J. Grottick, Kevin Whelan, et al. · Psychopharmacology · 13

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Works count: 44

Citation count: 1,236

H-index: 23

I10-index: 31