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Tomasz M. Kostrzewski

Observed names: Kostrzewski, Tomasz, T Kostrzewski, T. Kostrzewski, Tomasz Kostrzewski
ORCID: 0000-0001-6309-628X
Observed ORCID: 0000-0001-6309-628X
OpenAlex ID: A5074477230
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression
2014 · Victoria Male, Ilaria Nisoli, et al. · The Journal of Experimental Medicine · 210
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Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease
2017 · Tomasz Kostrzewski, Terri Cornforth, et al. · World Journal of Gastroenterology · 152
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Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
2016 · N. Tsamandouras, T. Kostrzewski, et al. · Journal of Pharmacology and Experimental Therapeutics · 119
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Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation
2020 · Andrés Rubiano, Amruta Indapurkar, et al. · Clinical and Translational Science · 100
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A Microphysiological System for Studying Nonalcoholic Steatohepatitis
2019 · Tomasz Kostrzewski, Paloma Maraver, et al. · Hepatology Communications · 81
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Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis
2020 · Michele Vacca, Jack Leslie, et al. · Nature Metabolism · 59
Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
2021 · Tomasz Kostrzewski, Sophie Snow, et al. · Communications Biology · 56
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Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins
2017 · Cliff Rowe, Mohsen Shaeri, et al. · Toxicology in Vitro · 39
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development
2018 · Tomasz Kostrzewski, Aaron J Borg, et al. · The Journal of Immunology · 37
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Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems
2017 · David J Hughes, Tomasz Kostrzewski, et al. · Experimental Biology and Medicine · 33
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models
2022 · Dharaminder Singh, Sudhir P. Deosarkar, et al. · PLoS Biology · 26
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Liver-on-chip model and application in predictive genotoxicity and mutagenicity of drugs
2024 · B. Kopp, A. Khawam, et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 22
A primary human Gut/Liver microphysiological system to estimate human oral bioavailability
2025 · Yassen Abbas, Morné van Wyk, et al. · Drug Metabolism and Disposition · 17
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
2022 · Ovidiu Novac, Raul Silva, et al. · Journal of Visualized Experiments · 16
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Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury
2025 · K. Taylor, R. Ram, et al. · Frontiers in Drug Discovery · 12
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Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings
2021 · Bhumika Singh, Mohamed Essameldin Abdelgawad, et al. · Alternatives to Laboratory Animals · 9
ILC Lineage Specification: To Be or Not 11b, That Is the Question
2015 · Tomasz Kostrzewski, Hugh J.M. Brady · Immunity · 4
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Abstract LB-044: In vitro assessment of combination dosing regimens with in vivo like pharmacokinetic concentration profiles enabled by a microfluidic addition and removal device
2018 · Paul Golby, Edoardo Buffa, et al. · Cancer Research · 2
Assessment of inhaled medications using an in vitro human alveolar microphysiological system.
2022 · E Richardson, H Sze, et al. · European Respiratory Journal · 1
Assessment of species-specific hepatotoxicity profiling in cross-species microphysiological system liver models
2026 · Isavella Georgiades, Justina Then, et al. · Journal of Pharmacological and Toxicological Methods
Introduction to the 3RsC's cross-platform microphysiological systems evaluation for drug-induced liver injury in collaboration with FDA-CDER
2026 · Megan R. LaFollette, Ksenia Blinova, et al. · Regulatory Toxicology and Pharmacology
Dynamic Culture Improves the Predictive Power of Bronchial and Alveolar Airway Models of SARS-CoV-2 Infection
2025 · Claire H Caygill, Rose Lopeman, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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P02-33 Bridging the gap: human and preclinical animal microphysiological systems for assessing drug-induced liver injury during drug discovery
2024 · C. Skarlatopoulou, O. Novac, et al. · Toxicology Letters
Improved predictivity of human drug oral bioavailability and first-pass metabolism utilizing human primary jejunum in a multi-organ intestinal-liver MPS system
2024 · Ashley Spreen, Yassen Abbas, et al. · Drug Metabolism and Pharmacokinetics
LP-35: A sensitive and robust human liver microphysiological system for assessing drug-induced liver injury
2023 · O. Novac, E. Richardson, et al. · Toxicology Letters
Works count: 35
Citation count: 994
H-index: 14
I10-index: 15
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