Get started
Author

John J. Barker

Observed names: J.J Barker, J.J. Barker, John Barker, John J Barker, John J. Barker
OpenAlex ID: A5103439885
High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds
1999 · S Luckett, R.Santiago Garcia, et al. · Journal of Molecular Biology · 400
Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction
1998 · Mark J Banfield, John J Barker, et al. · Structure · 221
PDF
Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex
2014 · Eric Jnoff, Claudia Albrecht, et al. · ChemMedChem · 190
The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design
1996 · Cameron R. Dunn, Mark J. Banfield, et al. · Nature Structural Biology · 176
Compound Design by Fragment‐Linking
2011 · Osamu Ichihara, John Barker, et al. · Molecular Informatics · 96
Antibacterial drug discovery and structure-based design
2006 · John J. Barker · Drug Discovery Today · 88
The Structure of Mammalian Serine Racemase
2010 · Myron A. Smith, Volker Mack, et al. · Journal of Biological Chemistry · 78
Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB
2016 · Michael F. Mesleh, Jason B. Cross, et al. · Bioorganic & Medicinal Chemistry Letters · 73
Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease
2012 · Michael E. Prime, Ole A. Andersen, et al. · Journal of Medicinal Chemistry · 70
The multiple roles of computational chemistry in fragment-based drug design
2009 · Richard Law, Oliver Barker, et al. · Journal of Computer-Aided Molecular Design · 60
Engineering an intertwined form of CD2 for stability and assembly
1998 · Alison J. Murray, Jared G. Head, et al. · Nature Structural Biology · 54
Discovery of a Novel Hsp90 Inhibitor by Fragment Linking
2010 · John J. Barker, Oliver Barker, et al. · ChemMedChem · 52
Fragment screening by biochemical assay
2006 · John Barker, Steve Courtney, et al. · Expert Opinion on Drug Discovery · 52
Fragment‐based Identification of Hsp90 Inhibitors
2009 · John J. Barker, Oliver Barker, et al. · ChemMedChem · 49
Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo
2015 · Jason D. Burch, Kathy Barrett, et al. · Journal of Medicinal Chemistry · 48
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
2016 · Jason B. Cross, Jing Zhang, et al. · ACS Medicinal Chemistry Letters · 46
Inhibitors of phosphopantetheine adenylyltransferase
2003 · Lihua Zhao, Nigel M. Allanson, et al. · European Journal of Medicinal Chemistry · 46
Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin-2 Inducible T-Cell Kinase Inhibitors
2014 · Jason D. Burch, Kevin Lau, et al. · Journal of Medicinal Chemistry · 45
Fragment-based discovery and optimization of BACE1 inhibitors
2010 · James Madden, Jenny R. Dod, et al. · Bioorganic & Medicinal Chemistry Letters · 42
Linking and fragmentation of alkynes at a triruthenium centre
1996 · Kerry J. Adams, John J. Barker, et al. · Journal of the Chemical Society Dalton Transactions · 31
Cross-linking of protein crystals as an aid in the generation of binary protein–ligand crystal complexes, exemplified by the human PDE10a–papaverine structure
2009 · Ole Andreas Andersen, Dorian Leo Schönfeld, et al. · Acta Crystallographica Section D Biological Crystallography · 29
Structure-based discovery of LpxC inhibitors
2017 · Jing Zhang, Audrey Chan, et al. · Bioorganic & Medicinal Chemistry Letters · 24
Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy
2023 · Kang Le, Michael J. Soth, et al. · Journal of Medicinal Chemistry · 23
Discovery of Novel UDP- N -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa
2021 · M. Dominic Ryan, Alastair L. Parkes, et al. · Journal of Medicinal Chemistry · 23
High‐resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand
2009 · Robert Cheng, Brunella Felicetti, et al. · Protein Science · 19
PDF
Works count: 51
Citation count: 2,150
H-index: 23
I10-index: 31
Year
Topic
Type