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Hiromu Harada

Observed names: HIROMU HARADA, Hiromu HARADA
Observed institution: Kissei Pharmaceutical (Japan)
OpenAlex ID: A5103639310
Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction
1990 · Kinji Iizuka, Tetsuhide Kamijo, et al. · Journal of Medicinal Chemistry · 94
Upregulation of Retinal Vascular Endothelial Growth Factor mRNAs in Spontaneously Diabetic Rats without Ophthalmoscopic Retinopathy
1998 · Yasunori Segawa, Yutaka Shirao, et al. · Ophthalmic Research · 60
A stereoselective synthesis of the (2R, 3S)- and (2S, 3R)-3-amino-2-hydroxybutyric acid derivatives, the key components of a renin inhibitor and bestatin.
1992 · Yuko Kobayashi, Yoshiji Takemoto, et al. · Tetrahedron · 51
A stereoselective synthesis of cyclohexylnorstatine, the key component of a renin inhibitor
1990 · Teruyo Matsumoto, Yuko Kobayashi, et al. · Tetrahedron Letters · 50
Design and synthesis of an orally potent human renin inhibitor containing a novel amino acid, cyclohexylnorstatine
1989 · Kinji Iizuka, Tetsuhide Kamijo, et al. · Journal of the Chemical Society Chemical Communications · 46
An improved and convenient synthesis of esters using 1,1'-carbonyldiimidazole and a reactive halide.
1984 · TETSUHIDE KAMIJO, HIROMU HARADA, et al. · Chemical and Pharmaceutical Bulletin · 30
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Studies on New Platelet Aggregation Inhibitors 1. Synthesis of 7-Nitro-3,4-dihydroquinoline-2(1H)-one Derivatives.
2001 · Akira IYOBE, Masahiko UCHIDA, et al. · Chemical and Pharmaceutical Bulletin · 28
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A useful reagent for the Beckmann rearrangement and the synthesis of nitriles from carboxamides: N,N'-carbonyldiimidazole and reactive halides.
1984 · TETSUHIDE KAMIJO, HIROMU HARADA, et al. · Chemical and Pharmaceutical Bulletin · 28
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An efficient synthesis of methyl N-[2-(R)-(1-napthylmethyl)-3-(morpholinocarbonyl)propionyl]-(S)-histidinate, the key synthetic intermediate of renin inhibitors
1990 · Yoshio Ito, Tetsuhide Kamijo, et al. · Tetrahedron Letters · 24
Novel Synthesis of Three Types of C-Terminal Components of Renin Inhibitors from Unnatural (2S,3S)-Tartaric Acid.
1991 · Yuko KOBAYASHI, Teruyo MATSUMOTO, et al. · Chemical and Pharmaceutical Bulletin · 21
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An improved and convenient procedure for the synthesis of 1-substituted imidazoles.
1983 · TETSUHIDE KAMIJO, RYOJI YAMAMOTO, et al. · Chemical and Pharmaceutical Bulletin · 21
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1-Substituted imidazoles as useful catalysts for acylation of alcohols.
1983 · TETSUHIDE KAMIJO, RYOJI YAMAMOTO, et al. · Chemical and Pharmaceutical Bulletin · 20
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A simple diastereoselective synthesis of cyclohexylnorstatine and allocyclohexylnorstatine.
1989 · Hiromu HARADA, Atsushi TSUBAKI, et al. · Chemical and Pharmaceutical Bulletin · 19
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A novel one step conversion of alcohols into alkyl bromides or iodides.
1983 · Tetsuhide Kamijo, Hiromu Harada, et al. · Chemical and Pharmaceutical Bulletin · 18
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A practical synthesis of the [(2R)-3-(morpholinocarbonyl)-2-(1-naphthylmethyl)propionyl]-L-histidine moiety (P4-P2) in renin inhibitors
1990 · Hiromu Harada, Toshiaki Yamaguchi, et al. · The Journal of Organic Chemistry · 17
1-Acyl-3-substituted imidazolium salts as highly reactive acylating agents.
1982 · Tetsuhide Kamijo, Ryoji Yamamoto, et al. · Chemical and Pharmaceutical Bulletin · 15
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A Novel Synthesis of Cyclohexylnorstatine Isopropyl Ester, the C-Terminal Component of a Renin Inhibitor
1990 · Shiro Terashima, Yoshio Ito, et al. · Heterocycles · 14
Studies on the Synthesis of Antiulcer Agents. II. Synthesis and Antiulcer Activity of Cyclic Carbamate Derivatives
1984 · MICHIHIRO KOBAYASHI, MAKIO KITAZAWA, et al. · YAKUGAKU ZASSHI · 7
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A practical synthesis of an orally potent renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidyl}aminobutyrate
1990 · Hiromu Harada, Akira Iyobe, et al. · Journal of the Chemical Society Perkin Transactions 1 · 6
New human renin inhibitory peptides. Angiotensinogen transition-state analogues containing novel Leu-Val replacement and a retro-inverso amide bond.
1988 · Kinji Iizuka, Tetsuhide Kamijo, et al. · Chemical and Pharmaceutical Bulletin · 5
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Studies on the Synthesis of Antiulcer Agents. I. Synthesis and Antiulcer Activity of Imide Derivatives
1984 · MICHIHIRO KOBAYASHI, MAKIO KITAZAWA, et al. · YAKUGAKU ZASSHI · 5
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ChemInform Abstract: Studies on New Platelet Aggregation Inhibitors. Part 1. Synthesis of 7‐Nitro‐3,4‐dihydroquinoline‐2(1H)‐one Derivatives.
2001 · Akira Iyobe, Masahiko Uchida, et al. · ChemInform · 1
Conformational study of a potent human renin inhibitor: X-ray crystal structure of isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidylamino}butyrate (KRI-1314), a pentapeptide analogue with amino acid sequence corresponding to the cleavage site of angiotensinogen
1991 · Mitsunobu Doi, Yasuko In, et al. · Journal of the Chemical Society Perkin Transactions 1 · 1
Subject Index
1998 · Kenji Katsuno, Akira Iyobe, et al. · Ophthalmic Research
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Author Index
1998 · Kenji Katsuno, Akira Iyobe, et al. · Ophthalmic Research
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Works count: 26
Citation count: 581
H-index: 15
I10-index: 17
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