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Takeshi Iijima

Observed name: Iijima, Takeshi
ORCID: 0009-0000-0305-9401
Observed ORCID: 0009-0000-0305-9401
OpenAlex ID: A5109282158
On the difficulty of validating molecular generative models realistically: a case study on public and proprietary data
2023 · Koichi Handa, Morgan C. Thomas, et al. · Journal of Cheminformatics · 34
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Prevalence of gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database
2020 · Shuichi Ito, Tomoko Torii, et al. · BMC Pediatrics · 31
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Prediction of Compound Plasma Concentration–Time Profiles in Mice Using Random Forest
2023 · Koichi Handa, Peter Wright, et al. · Molecular Pharmaceutics · 30
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Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption
2022 · Aoi Yoshitomo, Satoshi Asano, et al. · Drug Metabolism and Disposition · 17
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Urate-lowering therapy for gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database
2021 · Masataka Honda, Hideki Horiuchi, et al. · BMC Pediatrics · 16
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Development of a 2D-QSAR Model for Tissue-to-Plasma Partition Coefficient Value with High Accuracy Using Machine Learning Method, Minimum Required Experimental Values, and Physicochemical Descriptors
2023 · Koichi Handa, Seishiro Sakamoto, et al. · European Journal of Drug Metabolism and Pharmacokinetics · 12
Combined data-driven and mechanism-based approaches for human-intestinal-absorption prediction in the early drug-discovery stage
2023 · Koichi Handa, Sakae Sugiyama, et al. · Digital Discovery · 9
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Development of Novel Methods for QSAR Modeling by Machine Learning Repeatedly: A Case Study on Drug Distribution to Each Tissue
2024 · Koichi Handa, Saki Yoshimura, et al. · Journal of Chemical Information and Modeling · 8
A novel glucokinase activator TMG-123 causes long-lasting hypoglycemia and impairs spermatogenesis irreversibly in rats
2021 · Taiki Kobayashi, Takasumi Shimomoto, et al. · The Journal of Toxicological Sciences · 7
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Prediction of Inhibitory Activity against the MATE1 Transporter via Combined Fingerprint- and Physics-Based Machine Learning Models
2024 · Koichi Handa, Shunta Sasaki, et al. · Journal of Chemical Information and Modeling · 6
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Development of a Novel In Silico Classification Model to Assess Reactive Metabolite Formation in the Cysteine Trapping Assay and Investigation of Important Substructures
2024 · Yuki Umemori, Koichi Handa, et al. · Biomolecules · 6
A Practical In Silico Method for Predicting Compound Brain Concentration–Time Profiles: Combination of PK Modeling and Machine Learning
2024 · Koichi Handa, Daichi Fujita, et al. · Molecular Pharmaceutics · 5
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CDK4/6 inhibitor-induced bone marrow micronuclei might be caused by cell cycle arrest during erythropoiesis
2024 · Yuki Okada, Satsuki Chikura, et al. · Genes and Environment · 5
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The effects of long-lasting hypoglycemia on male reproductive organs in rats
2015 · Taiki Kobayashi, Junichi Namekawa, et al. · The Journal of Toxicological Sciences · 5
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An integrated population pharmacokinetic model of febuxostat in pediatric patients with hyperuricemia including gout and adult population of healthy subjects and patients with renal dysfunction
2024 · Ryutaro Iwama, Kimie Nishida, et al. · Pharmacology Research & Perspectives · 2
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On The Difficulty of Validating Molecular Generative Models Realistically: A Case Study on Public and Proprietary Data
2023 · Koichi Handa, Morgan Thomas, et al. · ChemRxiv · 1
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Antidiabetic agent did not impair spermatogenesis in spontaneously hyperglycemic and diabetic rats
2021 · Taiki Kobayashi, Takasumi Shimomoto, et al. · Fundamental Toxicological Sciences · 1
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Examination of immunosuppression by rat peripheral lymphocytes phenotyping : basic examination using rat peripheral blood after dosing DMBA, benzene, EGME (IMMUNE AND ALLERGIC SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
2003 · Satoko Kakiuchi, Daishiro Miura, et al. · The Journal of Toxicological Sciences · 1
21B-09-4 Evaluation of Colony-Forming Units assay using dog hematopoietic progenitor cells as a toxicological test system.
1999 · Daishiro Miura, Mitsuru Kobayashi, et al. · The Journal of Toxicological Sciences · 1
Abaloparatide increases bone mass by increasing bone formation regardless of alendronate pretreatment in mice
2025 · Akito Makino, Tomoka Hasegawa, et al. · Journal of Oral Biosciences
Development of a novel in silico classification model to assess reactive metabolite formation in cysteine trapping assay and investigation of important substructures
2024 · Yuki Umemori, Koichi Handa, et al. · Drug Metabolism and Pharmacokinetics
On The Difficulty of Validating Molecular Generative Models Realistically: A Case Study on Public and Proprietary Data
2023 · Koichi Handa, Morgan Thomas, et al. · ChemRxiv
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21B-10-3 Hematological and blood chemical study of the inhibitory effect on the hematopoietic system in the chemotherapeutics administered to rabbit.
1999 · Mitsuru Kobayashi, Daishiro Miura, et al. · The Journal of Toxicological Sciences
Works count: 30
Citation count: 197
H-index: 8
I10-index: 6
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