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Mark J. Thompson

Observed names: M. J. THOMPSON, M.J. Thompson, Mark J Thompson, Mark Thompson, Mark J. Thompson, Thompson, Mark J, Thompson, Mark J.
Observed institution: University of Sheffield
OpenAlex ID: A5112559151
Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
2017 · Susan E. Tsutakawa, Mark J. Thompson, et al. · Nature Communications · 110
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Catalytic Roles for Carbon-Oxygen Hydrogen Bonding in SET Domain Lysine Methyltransferases
2006 · Jean-François Couture, Glenn Hauk, et al. · Journal of Biological Chemistry · 83
Exploring Catalyst and Solvent Effects in the Multicomponent Synthesis of Pyridine-3,5-dicarbonitriles
2009 · Kai Guo, Mark J. Thompson, et al. · The Journal of Organic Chemistry · 80
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
2016 · Jack C Exell, Mark J Thompson, et al. · Nature Chemical Biology · 78
Synthesis and evaluation of a focused library of pyridine dicarbonitriles against prion disease
2007 · Kai Guo, Roger Mutter, et al. · European Journal of Medicinal Chemistry · 76
Ugi Reactions with Ammonia Offer Rapid Access to a Wide Range of 5-Aminothiazole and Oxazole Derivatives
2009 · Mark J. Thompson, Beining Chen · The Journal of Organic Chemistry · 71
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer
2015 · Helen E. Colley, Munitta Muthana, et al. · Journal of Medicinal Chemistry · 52
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Design, Synthesis, and Structure−Activity Relationship of Indole-3-glyoxylamide Libraries Possessing Highly Potent Activity in a Cell Line Model of Prion Disease
2009 · Mark J. Thompson, Vinciane Borsenberger, et al. · Journal of Medicinal Chemistry · 50
Mechanistic studies leading to a new procedure for rapid, microwave assisted generation of pyridine-3,5-dicarbonitrile libraries
2007 · Kai Guo, Mark J. Thompson, et al. · Tetrahedron · 47
Library Synthesis and Screening: 2,4-Diphenylthiazoles and 2,4-Diphenyloxazoles as Potential Novel Prion Disease Therapeutics
2007 · William Heal, Mark J. Thompson, et al. · Journal of Medicinal Chemistry · 45
4-Phosphopyrazol-2-yl alanine: a non-hydrolysable analogue of phosphohistidine
2015 · Matthew Lilley, Bezaleel Mambwe, et al. · Chemical Communications · 38
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A Small Molecule Modulator of Prion Protein Increases Human Mesenchymal Stem Cell Lifespan, Ex Vivo Expansion, and Engraftment to Bone Marrow in NOD/SCID Mice
2012 · Sindhu T. Mohanty, Claire J. Cairney, et al. · Stem Cells · 38
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Synthesis and Evaluation of 1‐Amino‐6‐halo‐β‐carbolines as Antimalarial and Antiprion Agents
2012 · Mark J. Thompson, Jennifer C. Louth, et al. · ChemMedChem · 36
ATP analogues with modified phosphate chains and their selectivity for rat P2X2 and P2X2/3 receptors
2003 · Valeria Spelta, Abdelaziz Mekhalfia, et al. · British Journal of Pharmacology · 33
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Synthesis of Two Stable Nitrogen Analogues of S-Adenosyl- l -methionine
1999 · Mark J. Thompson, Abdelaziz Mekhalfia, et al. · The Journal of Organic Chemistry · 33
Development of a Diversity-Oriented Approach to Oxazole-5-amide Libraries
2009 · Mark J. Thompson, Harry Adams, et al. · The Journal of Organic Chemistry · 29
Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling
2008 · Mark J. Thompson, Beining Chen · Tetrahedron Letters · 29
Synthesis of 5-aminothiazoles as building blocks for library synthesis
2006 · Mark J. Thompson, William Heal, et al. · Tetrahedron Letters · 28
DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction
2016 · Sana I. Algasaier, Jack C. Exell, et al. · Journal of Biological Chemistry · 25
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Structure–Activity Relationship Refinement and Further Assessment of Indole‐3‐glyoxylamides as a Lead Series against Prion Disease
2010 · Mark J. Thompson, Jennifer C. Louth, et al. · ChemMedChem · 25
Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity
2011 · Mark J. Thompson, Jennifer C. Louth, et al. · European Journal of Medicinal Chemistry · 23
A conserved loop–wedge motif moderates reaction site search and recognition by FEN1
2018 · Mark J Thompson, Victoria J B Gotham, et al. · Nucleic Acids Research · 17
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Regioselective Synthesis of 3-Aminoimidazo[1,2-a]-pyrimidines under Continuous Flow Conditions
2014 · Ashlie J. E. Butler, Mark J. Thompson, et al. · The Journal of Organic Chemistry · 16
Sugar conjugates of fulvestrant (ICI 182,780): efficient general procedures for glycosylation of the fulvestrant core
2003 · Mark J. Thompson, Edward J. Hutchinson, et al. · Tetrahedron Letters · 16
Homochiral synthesis of an aza analogue of S-adenosyl-L-methionine (AdoMet) and its binding to the E. coli methionine repressor protein (MetJ)
1996 · Mark J. Thompson, Abdelaziz Mekhalfia, et al. · Chemical Communications · 16
Works count: 49
Citation count: 1,167
H-index: 21
I10-index: 29
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