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Type 1 Diabetes-A Proposal for Prevention & Intervention

Description: PUBLIC HEALTH RELEVANCE: Type 1 diabetes imposes a tremendous burden on individuals, families, and society. Preventing or delaying the onset of T1D, the primary focus of TrialNet, would reduce costs to society and the suffering of affected individuals and their family.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2009-09-30
End date: 2020-04-30
Investigator: ANTOINETTE M. MORAN
Institution: UNIVERSITY OF MINNESOTA
Subfield: Genetics
Funded outputs count: 171
Funder award ID: U01DK085476
OpenAlex ID: G1980108060
β-Cell Dysfunction Identifies Individuals With Single Autoantibody Positivity at Increased Risk of Type 1 Diabetes Progression
2026 · Emily K. Sims, Lu You, et al. · Diabetes Care
Quantification of Proinsulin in Human Plasma by Proteolysis-Aided Peptide Immunoaffinity-Liquid Chromatography-Tandem Mass Spectrometry
2026 · Sara K Shijo, Elisha Goonatilleke, et al. · Clinical Chemistry
Islet Autoantibody Patterns Vary by Race and Ethnicity and Area Deprivation Index for Individuals at Risk for Type 1 Diabetes
2026 · Ananta Addala, Susanne Cabrera, et al. · Diabetes Care
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Extended Follow-up of Type 1 Diabetes Immunotherapy Trial Participants Suggests Benign Side Effect Profile
2026 · Laura M. Jacobsen, Dave Cuthbertson, et al. · Diabetes Care
Phase I Clinical Trial of Islet Antigen–Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes
2026 · Carla J. Greenbaum, S. Alice Long, et al. · Diabetes · 3
Type 2 Diabetes Genetic Risk and Type 1 Diabetes Heterogeneity and Progression
2025 · Taylor M. Triolo, Jay M. Sosenko, et al. · Diabetes · 3
Genetic Predictors of Response to Oral Insulin for Type 1 Diabetes Prevention
2025 · Lu You, Hemang M. Parikh, et al. · Diabetes Care
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Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort
2025 · Camille Préfontaine, Jasmine Pipella, et al. · Scientific Reports · 6
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Baseline Insulin Secretion Determines Response to Abatacept in Stage 1 Type 1 Diabetes
2025 · Alfonso Galderisi, Alice L.J. Carr, et al. · Diabetes · 4
Stage 1 type 1 diabetes memory B lymphocytes transcriptionally differ from healthy controls and harbor insulin-binding specificities
2025 · Lindsay E Bass, Wyatt J McDonnell, et al. · ImmunoHorizons · 2
Neutrophil-enriched gene signature correlates with teplizumab therapy resistance in different stages of type 1 diabetes
2025 · Gabriele Sassi, Pierre Lemaitre, et al. · Journal of Clinical Investigation · 4
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Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval
2025 · Emily K. Sims, William E. Russell, et al. · Diabetes · 3
Contrasting Adult and Pediatric Populations in a Cohort of At-Risk Relatives in The T1D TrialNet Pathway to Prevention Study
2025 · Erin L. Templeman, Lauric A. Ferrat, et al. · Diabetes Care · 25
Development and recalibration of a multivariable type 1 diabetes prediction model for type 1 diabetes across multiple screening studies
2025 · Erin L. Templeman, Lauric A. Ferrat, et al. · BMC Medicine · 7
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Genetic Risk and Transition Through Preclinical Stages of Type 1 Diabetes
2025 · Andrea K Steck, Hemang M Parikh, et al. · The Journal of Clinical Endocrinology & Metabolism · 5
Evaluation of proinsulin(F25D) as a targeting ligand for insulin-binding B cells in autoimmune diabetes
2025 · Kyle D. Apley, Lindsay E. Bass, et al. · Drug Delivery and Translational Research · 4
Type 1 Diabetes TrialNet: Leading the Charge in Disease Prediction, Prevention, and Immunotherapeutic Mechanistic Understanding
2025 · Laura M. Jacobsen, Jamie L. Felton, et al. · Diabetes Care · 19
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M120 Risk Score Improves Identification of Children at High Risk of Developing Clinical Type 1 Diabetes and Reports Short-term Response to Preventive Immunotherapy
2025 · Minh V. Le,, Leonard C. Harrison, et al. · Diabetes Care · 4
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The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes
2025 · Heba M. Ismail, David Cuthbertson, et al. · Diabetes · 6
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Activated polyreactive B cells are clonally expanded in autoantibody positive and patients with recent-onset type 1 diabetes
2025 · Catherine A. Nicholas, Fatima A. Tensun, et al. · Cell Reports · 12
Comparative Analysis of the Sensitivity, Specificity, Concordance, and 5-Year Predictive Power of Diabetes-Related Autoantibody Assays
2025 · Jeffrey P. Krischer, Sarah Muller, et al. · Diabetes · 14
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IA-2A positivity increases risk of progression within and across established stages of type 1 diabetes
2025 · Emily K. Sims, David Cuthbertson, et al. · Diabetologia · 26
Metabolic Phenotype of Stage 1 and Stage 2 Type 1 Diabetes Using Modeling of β Cell Function
2025 · Alfonso Galderisi, Jacopo Bonet, et al. · The Journal of Clinical Endocrinology & Metabolism · 9
A Glucose Fraction Independent of Insulin Secretion: Implications for Type 1 Diabetes Progression in Autoantibody-Positive Cohorts
2025 · Jay M. Sosenko, David Cuthbertson, et al. · Diabetes Technology & Therapeutics · 2
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Enhancing Type 1 Diabetes Immunological Risk Prediction with Continuous Glucose Monitoring and Genetic Profiling
2024 · Eslam Montaser, Leon S. Farhy, et al. · Diabetes Technology & Therapeutics · 36
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