Phenotypic and Molecular Signatures for Sleep Apnea and Related Morbidities
Description: Sleep apnea is a common disorder associated with many adverse health outcomes, but often unrecognized and under-treated. The usual measure of disease severity, the Apnea Hypopnea Index, does not adequately characterize disease subtypes reflective of differences in underlying anatomic and physiological risk factors, and thus poorly predicts which patients are most susceptible to adverse health outcomes and would benefit from treatment. The mainstay treatment is a CPAP machine, which stents the airway open without treating the underlying cause of the apnea. This program will systematically identify new measures of sleep apnea that reflect underlying mechanisms and allow subgroups of patients to be better characterized, facilitating the discovery of the molecular basis for sleep apnea and novel treatments.
Funding type: research
Funder scheme: R35
Start date: 2017-01-01
End date: 2023-12-31
Investigator: SUSAN S. REDLINE
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 341
Funder award ID: R35HL135818
OpenAlex ID: G3228752415