Nitric oxide-mediated changes in glymphatic and CSF systems in aging and Alzheimer’s disease
Description: NARRATIVE Brain has to continuously clear itself from the accumulating waste, up to half a pound of detritus a month. Recently, a new network for transporting the waste out of the brain has been described. This system, dubbed glymphatics, is also necessary for removing toxic proteins that characterize aging and Alzheimer's disease; therefore, glymphatics arises as a potential new target for designing new therapies for Alzheimer's and other neurodegenerative diseases. Here we introduce nitric oxide (NO) as a new player regulating glymphatic transport and propose a series of experiments tailored to answer whether NO deficiency contributes to the deterioration of glymphatic transport during aging and Alzheimer's and whether NO-based therapies may be used to improve or rescue the glymphatic transport and improve waste clearance in the brain.
Funder: National Institute on Aging
Funding type: research
Funder scheme: RF1
Start date: 2017-09-15
End date: 2022-08-31
Investigator: HELENE D BENVENISTE
Institution: STATE UNIVERSITY NEW YORK STONY BROOK
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 26
Funder award ID: RF1AG057705
OpenAlex ID: G2920505873