Characterizing the glymphatic peri-vascular connectome and its disruption in AD
Description: PROJECT NARRATIVE We propose to develop an imaging “biomarker” to identify the changes in the ‘glymphatic’ system that occur due to normal aging and, in particular, following deposition of amyloid plaques. Pre-clinical studies show that the glymphatic system is involved with brain-wide metabolic waste clearance, including removal of beta- amyloid. The glymphatic biomarker will be used to detect early-stage disease such as vascular amyloidosis with deposits in the small blood vessels and/or within the brain tissue itself. The goal is to understand how dysfunction of the glymphatic system contributes to further amyloid buildup evident in Alzheimer’s disease and to cognitive deficits. The novel studies will be performed in two different (and new) transgenic rat models of amyloid disease which closely mimic the human conditions of cerebral vascular or parenchymal amyloid pathologies.
Funder: National Institute on Aging
Funding type: research
Funder scheme: RF1
Start date: 2016-08-01
End date: 2021-08-31
Investigator: HELENE D BENVENISTE
Institution: YALE UNIVERSITY
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 49
Funder award ID: RF1AG053991
OpenAlex ID: G3913676021