Anti-cytomegalovirus Immune Responses in Atherosclerotic Cardiovascular Disease in Persons Living with HIV
Description: Narrative Persons with HIV (PWH) on antiretroviral therapy have an increasing risk of mortality from cardiovascular disease that is likely multifactorial. Chronic inflammation due to co-infection with cytomegalovirus (CMV) alters the memory T cell repertoire and antibody responses and is likely important in the pathogenesis of cardiovascular disease. This proposal focuses on the role of CMV-specific immune cells in the progression of atherosclerotic disease in PWH; aligning with the NIH HIV/AIDS research priorities and NHLBI's mission to investigate newly discovered pathobiological mechanisms important to the onset of atherosclerotic cardiovascular disease and identify factors that account for differences in health among populations.
Funding type: career_development
Funder scheme: K23
Start date: 2021-08-25
End date: 2026-07-31
Investigator: CELESTINE N WANJALLA
Institution: VANDERBILT UNIVERSITY MEDICAL CENTER
Funded outputs count: 39
Funder award ID: K23HL156759
OpenAlex ID: G9000916097