Identification of a novel targetable cancer stem cell regulator promoting cancer progression and metastasis in non-small cell lung cancer
Description: Advanced non-small cell lung cancer (NSCLC) accounting for 85% of lung cancer is a highly aggressive cancer with poor prognosis and short survival rate. The goal of this study is to characterize a novel and unique cancer stem cell (CSC) population in NSCLC progression and metastasis and dissect its regulatory mechanisms that can be harnessed for developing a novel effective strategy for targeting progression and metastasis of NSCLC and overcoming the resistance to current standard of care treatments. Our proposal represents a paradigm- shifting concept in that the successful implementation of our proposal will not only reveal new insight into CSC regulation leading to cancer progression and metastasis, but also offer a new strategy for targeting advanced NSCLC with metastasis.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2023-02-09
End date: 2028-01-31
Investigator: HUI-KUAN LIN (lead)
Institution: Duke University
Funded outputs count: 8
Funder award ID: R01CA270617
OpenAlex ID: G9000897572