Integration of Lepr circuits for thermoregulation and energy status
Description: In humans and rodents, physiological adaptations of food intake and energy expenditure ensure the maintenance body temperature and body weight during environmental challenges of ambient temperature or fasting, but those adaptations are also a major hurdle to maintain weight loss after dieting in obese patients. We identified a population of neurons that respond to the hormone leptin that modulates physiological adaptations in response to ambient temperature and fasting, and represents an excellent model to investigate the neuronal circuits that integrate physiological adaptations to temperature and energy state. This proposal aims to work towards a cohesive model how physiological adaptations are mediated in the brain and has implications for metabolic studies in humans and animals that guide treatment strategies for weight loss in obese patients.
Funding type: research
Funder scheme: R01
Start date: 2012-07-01
End date: 2026-06-30
Investigator: HEIKE MUENZBERG-GRUENING
Institution: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 71
Funder award ID: R01DK092587
OpenAlex ID: G6597286818