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Neural mechanisms controlling food intake and body weight after bariatric surgery

Description: PUBLIC HEALTH RELEVANCE: Bariatric surgery is currently the most effective treatment of obesity and its associated health problems such as diabetes, cardiovascular disease, and sleep disturbances. This proposal investigates neural mechanisms responsible for the surgery-induced reduction in appetite and body weight, so that new pharmacological and behavioral treatments can be developed without the need for surgery.

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Funding type: research

Funder scheme: R01

Start date: 1994-08-20

End date: 2020-09-30

Investigator: HANS-RUDOLF BERTHOUD

Institution: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

Topic: Bariatric Surgery and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

Funded outputs count: 137

Funder award ID: R01DK047348

OpenAlex ID: G8913820038

Anatomy and function of efferent and afferent vagal innervation of the stomach

2026 · Hans-Rudolf Berthoud, Heike Münzberg, et al. · Autonomic Neuroscience

Vagal sensory neurons profusely innervate the mouse gall bladder

2026 · Winfried L. Neuhuber, Sangho Yu, et al. · Autonomic Neuroscience

Brunner's Glands in the Duodenal Bulb Are Indirectly Innervated by Vagal Preganglionics That Connect With Cholinergic Enteric Neurons in the Myenteric Plexus

2026 · Heike Münzberg, Jaclyn Williams, et al. · The Journal of Comparative Neurology

Direct vagal input to the gastrointestinal tract and other viscera: Re-definition of autonomic neuroscience or experimental artifacts?

2025 · Hans-Rudolf Berthoud, Edward A. Fox, et al. · Autonomic Neuroscience · 12

Gut-brain communication: Functional anatomy of vagal afferents

2025 · Hans-Rudolf Berthoud, Heike Münzberg, et al. · Current Opinion in Neurobiology · 24

Leptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss

2024 · Marie Francois, Laura Kaiser, et al. · Metabolism · 19

Hepatic interoception in health and disease

2024 · Hans-Rudolf Berthoud, Heike Münzberg, et al. · Autonomic Neuroscience · 16

Sensory spinal interoceptive pathways and energy balance regulation

2023 · Heike Münzberg, Hans-Rudolf Berthoud, et al. · Molecular Metabolism · 35

Reduction of Plasma BCAAs following Roux-en-Y Gastric Bypass Surgery Is Primarily Mediated by FGF21

2023 · Harsh Shah, Alyssa Kramer, et al. · Nutrients · 16

The PYY/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass

2022 · Bita Zahedi, Eileen J. Daley, et al. · Bone · 4

Functional anatomy of the vagus system: How does the polyvagal theory comply?

2022 · Winfried L. Neuhuber, Hans-Rudolf Berthoud · Biological Psychology · 42

Regulation of body weight: Lessons learned from bariatric surgery

2022 · Vance L. Albaugh, Yanlin He, et al. · Molecular Metabolism · 77

FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice

2022 · Cristal M. Hill, Diana C. Albarado, et al. · Nature Communications · 117

Functional anatomy of the vagus system – Emphasis on the somato-visceral interface

2021 · Winfried L. Neuhuber, Hans-Rudolf Berthoud · Autonomic Neuroscience · 77

Learning of food preferences: mechanisms and implications for obesity & metabolic diseases

2021 · Hans-Rudolf Berthoud, Christopher D. Morrison, et al. · International Journal of Obesity · 73

Gut-brain communication and obesity: understanding functions of the vagus nerve

2021 · Hans-Rudolf Berthoud, Vance L. Albaugh, et al. · Journal of Clinical Investigation · 109

IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery

2021 · Justine Faramia, Zheng Hao, et al. · Cell Reports Medicine · 43

The obesity epidemic in the face of homeostatic body weight regulation: What went wrong and how can it be fixed?

2020 · Hans-Rudolf Berthoud, Christopher D. Morrison, et al. · Physiology & Behavior · 53

Faculty Opinions recommendation of Unlike calorie restriction, Roux-en-Y gastric bypass surgery does not increase hypothalamic AgRP and NPY in mice on a high-fat diet.

2020 · Heike Münzberg · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Joint international consensus statement for ending stigma of obesity

2020 · Francesco Rubino, Rebecca M. Puhl, et al. · Nature Medicine · 1,152

FGF21 and the Physiological Regulation of Macronutrient Preference

2020 · Cristal M Hill, Emily Qualls-Creekmore, et al. · Endocrinology · 99

Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease

2019 · Hans‐Rudolf Berthoud, Winfried L. Neuhuber · Annals of the New York Academy of Sciences · 74

FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

2019 · Cristal M. Hill, Thomas Laeger, et al. · Cell Reports · 229

Gastric bypass surgery in lean adolescent mice prevents diet-induced obesity later in life

2019 · Michael B. Mumphrey, Zheng Hao, et al. · Scientific Reports · 8

Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice

2019 · Brandon B. Boland, Michael B. Mumphrey, et al. · Molecular Metabolism · 36