FGF21-dependent mechanisms driving changes in energy expenditure during dietary protein restriction
Description: Project Narrative This project seeks to identify novel mechanisms which mediate the effects of dietary protein intake on energy expenditure. There is ample evidence that dietary protein impacts metabolism and health, and our lab recently discovered that the hormone FGF21 is essential for metabolic responses to protein restriction. This project seeks to define how FGF21 signaling within the brain alters metabolism and the extent to which the FGF21- dependent remodeling of adipose tissue contributes to the beneficial metabolic effects of dietary protein restriction. It is expected that this work will uncover fundamentally new pathways linking diet to metabolic health.
Funding type: research
Funder scheme: R01
Start date: 2020-05-15
End date: 2025-02-28
Investigator: CHRISTOPHER D MORRISON
Institution: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 13
Funder award ID: R01DK121370
OpenAlex ID: G5112683807