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Estrogen and cognition over the lifespan

Description: Narrative Estradiol (E2) is protective against neurodegenerative diseases, including Alzheimer’s disease, implicating sex hormone effects on sex differences in vulnerability. The proposal addresses mechanisms for long-term E2 effects on synaptic transmission and a possible mechanism (DNA methylation) for a decline in the efficacy of hormone treatment in advanced age through epigenetic regulation of E2-responsive transcription profile.
Funding type: research
Funder scheme: R01
Start date: 2010-09-15
End date: 2024-03-31
Investigator: THOMAS C FOSTER
Institution: UNIVERSITY OF FLORIDA
Field: Medicine
Funded outputs count: 66
Funder award ID: R01AG037984
OpenAlex ID: G1945097447
Serine racemase expression profile in the prefrontal cortex and hippocampal subregions during aging in male and female rats
2024 · Linda Bean, Prodip K. Bose, et al. · Aging · 2
Senolytic treatment alleviates doxorubicin‐induced chemobrain
2024 · Vivekananda Budamagunta, Ashok Kumar, et al. · Aging Cell · 32
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Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection
2023 · Valerie E. Polcz, Evan L. Barrios, et al. · Clinical Science · 15
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Viral vector-mediated upregulation of serine racemase expression in medial prefrontal cortex improves learning and synaptic function in middle age rats
2023 · Brittney Yegla, Asha Rani, et al. · Aging · 1
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Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain
2023 · Jessica A. Peterson, Joshua A. Crow, et al. · Frontiers in Aging Neuroscience · 12
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Effect of peripheral cellular senescence on brain aging and cognitive decline
2023 · Vivekananda Budamagunta, Ashok Kumar, et al. · Aging Cell · 65
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Epigenetic aging, knee pain and physical performance in community-dwelling middle-to-older age adults
2022 · Jessica A. Peterson, Lingsong Meng, et al. · Experimental Gerontology · 19
Sex differences associate with late microbiome alterations after murine surgical sepsis
2022 · Philip Alexander Efron, Dijoia B. Darden, et al. · The Journal of Trauma: Injury, Infection, and Critical Care · 24
Exosomes in Age-Related Cognitive Decline: Mechanistic Insights and Improving Outcomes
2022 · Michael R. Duggan, Anne Lu, et al. · Frontiers in Aging Neuroscience · 15
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Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis
2022 · Asha Rani, Jolie Barter, et al. · Aging · 22
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Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline
2021 · Jolie Barter, Ashok Kumar, et al. · Aging · 29
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Cellular senescence in lymphoid organs and immunosenescence
2021 · Vivekananda Budamagunta, Thomas C. Foster, et al. · Aging · 67
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Senescence-associated hyper-activation to inflammatory stimuli in vitro
2021 · Vivekananda Budamagunta, Sahana Manohar-Sindhu, et al. · Aging · 54
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Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen’s Critical Window
2021 · Puja Sinha, Asha Rani, et al. · Frontiers in Aging Neuroscience · 8
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Partial microglial depletion is associated with impaired hippocampal synaptic and cognitive function in young and aged rats
2021 · Brittney Yegla, Jake Boles, et al. · Glia · 33
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies
2021 · Joseph A. McQuail, Amy R. Dunn, et al. · Frontiers in Aging Neuroscience · 64
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MicroRNA predicts cognitive performance in healthy older adults
2020 · Joseph M. Gullett, Zhaoyi Chen, et al. · Neurobiology of Aging · 34
Differential Effect of Repeated Lipopolysaccharide Treatment and Aging on Hippocampal Function and Biomarkers of Hippocampal Senescence
2020 · Jolie Barter, Ashok Kumar, et al. · Molecular Neurobiology · 15
Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging
2020 · Garrett Smith, Asha Rani, et al. · Journal of Neuroscience · 23
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Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory
2020 · Marcelo Febo, Asha Rani, et al. · Frontiers in Aging Neuroscience · 36
Enrichment of genomic pathways based on differential DNA methylation profiles associated with chronic musculoskeletal pain in older adults: An exploratory study
2020 · Soamy Montesino-Goicolea, Puja Sinha, et al. · Molecular Pain · 18
GSTA4 mediates reduction of cisplatin ototoxicity in female mice
2019 · Hyo-Jin Park, Mi-Jung Kim, et al. · Nature Communications · 53
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Senescent neurophysiology: Ca2+ signaling from the membrane to the nucleus
2019 · Thomas C. Foster · Neurobiology of Learning and Memory · 16
Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging
2019 · Ashok Kumar, Jeffrey S. Thinschmidt, et al. · Aging · 39
Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis
2019 · Jolie Barter, Ashok Kumar, et al. · Molecular Neurobiology · 49
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