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Retinoids in Vision

Description: NARRATIVE Key processes in vision include the absorption of light by retinal rod and cone cells, triggering a phototransduction cascade that transforms the visual pigments and propagates an electrical signal to the brain, followed by regeneration of these pigments through the visual cycle. Despite significant advances in understanding the chemistry and biology of these pathways, fundamental questions remain. A deeper comprehension of these processes is crucial for elucidating the causes of human blinding diseases and developing innovative therapies to improve medical practice.
Funding type: research
Funder scheme: R01
Start date: 1992-01-01
End date: 2028-08-31
Investigator: PHILIP DAVID KISER
Institution: UNIVERSITY OF CALIFORNIA-IRVINE
Funded outputs count: 308
Funder award ID: R01EY009339
OpenAlex ID: G9000892366
2026 · Hyewon Jang, Carolline Rodrigues Menezes, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2026 · Roman Smidak, Deepak Poria, et al. · Proceedings of the National Academy of Sciences
2026 · Marco Bassetto, Bowen Li, et al. · Journal of the American Chemical Society
2026 · Siying Lin, Francesca Cancellieri, et al. · The American Journal of Human Genetics
2026 · Balasankara Reddy Kaipa, Linya Li, et al. · JCI Insight · 1
2026 · Jianye Zhang, Rafał Hołubowicz, et al. · Nature Communications · 1
2026 · David Salom, Diana S. Suder, et al. · Proceedings of the National Academy of Sciences
2026 · Salom, David, Suder, Diana, et al. · DRYAD
2026 · Dorota Skowronska-Krawczyk, Emily Tom, et al. · Research Square
2025 · Elias Roihuvuo, Lee Sturgis, et al. · Investigative Ophthalmology & Visual Science · 1
2025 · Zachary J. Engfer, Grazyna Palczewska, et al. · Journal of Clinical Investigation · 3
2025 · Rafal Hołubowicz, Fangyuan Gao, et al. · Journal of Biological Chemistry · 6
2025 · Samuel W. Du, Grazyna Palczewska, et al. · Proceedings of the National Academy of Sciences · 5
2025 · Marco Bassetto, Yulun Hu, et al. · Journal of Medicinal Chemistry · 4
2025 · Aleksander Tworak, Roman Smidak, et al. · Proceedings of the National Academy of Sciences · 5
2025 · Julian Geilenkeuser, Niklas Armbrust, et al. · Cell · 54
2025 · Sławomir Tomczewski, Andrea Curatolo, et al. · Proceedings of the National Academy of Sciences · 22
2025 · Sonja Lindfors, Constanze Schmotz, et al. · Journal of the American Society of Nephrology · 4
2025 · David Salom, Krzysztof Palczewski · Journal of Structural Biology
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