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The Clinical Profile of Parkinson's Disease (PD) Pathology

Description: The overall goal of this project is to characterize the clinical profile of Parkinson's disease (PD) pathology in older person's without a diagnosis of PD. Showing that PD pathology is associated with a distinct and progressive condition among persons without a clinical diagnosis of PD, would have a transformative effect on PD studies, in terms of potential biomarkers, early detection and interventions to delay the onset of PD.
Funding type: research
Funder scheme: R01
Start date: 2012-09-15
End date: 2018-06-30
Investigator: ARON S BUCHMAN
Institution: RUSH UNIVERSITY MEDICAL CENTER
Subfield: Neurology
Field: Medicine
Funded outputs count: 98
Funder award ID: R01NS078009
OpenAlex ID: G4921545413
Haplotype-resolved DNA methylation at the APOE locus identifies allele-specific epigenetic signatures relevant to Alzheimer’s disease risk
2026 · Rylee M. Genner, Melissa Meredith, et al. · npj Dementia · 1
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Dysregulation of Inositol Polyphosphate 5-Phosphatase OCRL in Alzheimer’s Disease: Implications for Autophagy Dysfunction
2025 · Kunie Ando, May Thazin Htut, et al. · International Journal of Molecular Sciences · 4
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GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia
2024 · Lincoln M. P. Shade, Yuriko Katsumata, et al. · Nature Genetics · 71
Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus
2023 · Chloé Sarnowski, Tianxiao Huan, et al. · Clinical Epigenetics · 21
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Volumetric brain correlates of gait associated with cognitive decline in community-dwelling older adults
2023 · Victoria N. Poole, Shahram Oveisgharan, et al. · Frontiers in Aging Neuroscience · 8
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Genome-wide association study of multiple neuropathology endophenotypes identifies novel risk loci and provides insights into known Alzheimer’s risk loci
2022 · Lincoln M.P. Shade, Yuriko Katsumata, et al. · medRxiv · 1
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Fragmentation of rest periods, astrocyte activation, and cognitive decline in older adults with and without Alzheimer's disease
2022 · Rebecca Wu, Shreejoy Tripathy, et al. · Alzheimer s & Dementia · 28
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Integrating multi-omics summary data using a Mendelian randomization framework
2022 · Chong Jin, Brian Lee, et al. · Briefings in Bioinformatics · 35
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Dividing attention during the Timed Up and Go enhances associations of several subtask performances with MCI and cognition
2022 · Victoria N. Poole, Robert J. Dawe, et al. · PLoS ONE · 11
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Neurodegenerative and Cerebrovascular Brain Pathologies Are Differentially Associated With Declining Grip Strength and Gait In Older Adults
2022 · Shahram Oveisgharan, Lei Yu, et al. · The Journals of Gerontology Series A · 19
Association of Statins With Cerebral Atherosclerosis and Incident Parkinsonism in Older Adults
2022 · Shahram Oveisgharan, Lei Yu, et al. · Neurology · 27
Genome-wide association study of brain arteriolosclerosis
2022 · Lincoln MP Shade, Yuriko Katsumata, et al. · Journal of Cerebral Blood Flow & Metabolism · 4
Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer’s and Parkinson’s Diseases
2021 · Simon Lam, Nils Hartmann, et al. · Biomedicines · 24
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Frequency of Parkinsonism and Parkinson Disease in African Americans in the Chicago Community
2021 · Meagan Bailey, Lisa M Shulman, et al. · The Journals of Gerontology Series A · 7
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Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults
2021 · Shahram Oveisgharan, Lei Yu, et al. · PLoS ONE · 15
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Underlying features of epigenetic aging clocks in vivo and in vitro
2020 · Zuyun Liu, Diana Leung, et al. · Aging Cell · 227
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Automatic Quantification of Tandem Walking Using a Wearable Device: New Insights Into Dynamic Balance and Mobility in Older Adults
2020 · Natalie Ganz, Eran Gazit, et al. · The Journals of Gerontology Series A · 11
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Dietary antioxidants associated with slower progression of parkinsonian signs in older adults
2020 · Puja Agarwal, Yamin Wang, et al. · Nutritional Neuroscience · 29
Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer’s dementia
2019 · Kirusanthy Kaneshwaran, Marta Olah, et al. · Science Advances · 99
What happens before the first step? A New Approach to Quantifying Gait Initiation Using a Wearable Sensor
2019 · Eran Gazit, Aron S. Buchman, et al. · Gait & Posture · 21
More random motor activity fluctuations predict incident frailty, disability, and mortality
2019 · Peng Li, Andrew S. P. Lim, et al. · Science Translational Medicine · 46
Neocortical Lewy bodies are associated with impaired odor identification in community-dwelling elders without clinical PD
2019 · Sukriti Nag, Lei Yu, et al. · Journal of Neurology · 22
Interaction between the progression of Alzheimer's disease and fractal degradation
2019 · Peng Li, Lei Yu, et al. · Neurobiology of Aging · 27
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Different Combinations of Mobility Metrics Derived From a Wearable Sensor Are Associated With Distinct Health Outcomes in Older Adults
2019 · Aron S Buchman, Robert J Dawe, et al. · The Journals of Gerontology Series A · 53
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Quantitative mobility metrics from a wearable sensor predict incident parkinsonism in older adults
2019 · Rainer von Coelln, Robert J. Dawe, et al. · Parkinsonism & Related Disorders · 32
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