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Neural circuits coordinating protein intake: Role of FGF21

Description: Project Narrative Despite the importance of dietary composition and food choice to health, and despite persistent dietary advice to change eating habits, we know almost nothing about how the brain controls dietary macronutrient choice. This project will define the brain areas and neural phenotypes mediating FGF21-dependent changes in feeding behavior, thereby uncovering a novel set of neural circuits that regulate food choice.
Funding type: research
Funder scheme: R01
Start date: 2020-09-15
End date: 2025-07-31
Investigator: CHRISTOPHER D MORRISON
Institution: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
Funded outputs count: 17
Funder award ID: R01DK123083
OpenAlex ID: G3250402675
FGF21-dependent and -independent liver transcriptomic adaptations to low-protein feeding during aging
2026 · Jose A. Godoy-Lugo, Khristina E. Young, et al. · npj Aging
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Vagal sensory neurons profusely innervate the mouse gall bladder
2026 · Winfried L. Neuhuber, Sangho Yu, et al. · Autonomic Neuroscience
Brunner's Glands in the Duodenal Bulb Are Indirectly Innervated by Vagal Preganglionics That Connect With Cholinergic Enteric Neurons in the Myenteric Plexus
2026 · Heike Münzberg, Jaclyn Williams, et al. · The Journal of Comparative Neurology
FGF21 signals through hindbrain neurons to alter food intake and energy expenditure during dietary protein restriction
2026 · Redin A. Spann, Sora Q. Kim, et al. · Cell Reports · 3
Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK ‐ ULK1 ‐Mediated Mitochondrial Quality Control
2026 · Wagner S. Dantas, Elizabeth R. M. Zunica, et al. · Aging Cell · 4
Low protein-induced-FGF-21 signaling remodels adipose tissue on reduced markers of senescence during aging
2025 · Jose G. Godoy-Lugo, Khristina E. Young, et al. · GeroScience · 3
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Gut-brain communication: Functional anatomy of vagal afferents
2025 · Hans-Rudolf Berthoud, Heike Münzberg, et al. · Current Opinion in Neurobiology · 24
FGF21 signals through KLB-expressing glutamatergic neurons in the hindbrain to mediate the effects of dietary protein restriction
2025 · Redin A. Spann, Sora Q. Kim, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling
2024 · Md Shahjalal H. Khan, Sora Q. Kim, et al. · Molecular Metabolism · 26
History and future of leptin: Discovery, regulation and signaling
2024 · Heike Münzberg, Steven B. Heymsfield, et al. · Metabolism · 30
FGF21 as a mediator of adaptive changes in food intake and macronutrient preference in response to protein restriction
2024 · Sora Q. Kim, Redin A. Spann, et al. · Neuropharmacology · 12
Reduction of Plasma BCAAs following Roux-en-Y Gastric Bypass Surgery Is Primarily Mediated by FGF21
2023 · Harsh Shah, Alyssa Kramer, et al. · Nutrients · 16
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Regulation of body weight: Lessons learned from bariatric surgery
2022 · Vance L. Albaugh, Yanlin He, et al. · Molecular Metabolism · 77
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FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice
2022 · Cristal M. Hill, Diana C. Albarado, et al. · Nature Communications · 117
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Dynamic effects of dietary protein restriction on body weights, food consumption, and protein preference in C57BL /6J and Fgf21 ‐KO mice
2022 · Francis Torres, Shahjalal Khan, et al. · Journal of the Experimental Analysis of Behavior · 12
Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis
2021 · Md Shahjalal Khan, Redin A. Spann, et al. · Nutrients · 34
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Learning of food preferences: mechanisms and implications for obesity & metabolic diseases
2021 · Hans-Rudolf Berthoud, Christopher D. Morrison, et al. · International Journal of Obesity · 73
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