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An Atlanta TrialNet Center: Building a Pathway to 70 Clinical Trial Subjects per Year

Description: PUBLIC HEALTH RELEVANCE: Type 1 diabetes causes profound health complications and early death for as many as 3 million Americans. The TrialNet consortium aims to find treatments that prevent or delay the onset of type 1 diabetes. This proposal outlines methods for recruiting and retaining eligible participants in TrialNet throughout the Atlanta Metropolitan Service Area.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2015-07-20
End date: 2021-04-30
Investigator: ANDREW B MUIR
Institution: EMORY UNIVERSITY
Subfield: Genetics
Funded outputs count: 109
Funder award ID: U01DK106994
OpenAlex ID: G8135711613
β-Cell Dysfunction Identifies Individuals With Single Autoantibody Positivity at Increased Risk of Type 1 Diabetes Progression
2026 · Emily K. Sims, Lu You, et al. · Diabetes Care
Quantification of Proinsulin in Human Plasma by Proteolysis-Aided Peptide Immunoaffinity-Liquid Chromatography-Tandem Mass Spectrometry
2026 · Sara K Shijo, Elisha Goonatilleke, et al. · Clinical Chemistry
Islet Autoantibody Patterns Vary by Race and Ethnicity and Area Deprivation Index for Individuals at Risk for Type 1 Diabetes
2026 · Ananta Addala, Susanne Cabrera, et al. · Diabetes Care
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Extended Follow-up of Type 1 Diabetes Immunotherapy Trial Participants Suggests Benign Side Effect Profile
2026 · Laura M. Jacobsen, Dave Cuthbertson, et al. · Diabetes Care
Phase I Clinical Trial of Islet Antigen–Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes
2026 · Carla J. Greenbaum, S. Alice Long, et al. · Diabetes · 3
Type 2 Diabetes Genetic Risk and Type 1 Diabetes Heterogeneity and Progression
2025 · Taylor M. Triolo, Jay M. Sosenko, et al. · Diabetes · 3
Genetic Predictors of Response to Oral Insulin for Type 1 Diabetes Prevention
2025 · Lu You, Hemang M. Parikh, et al. · Diabetes Care
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Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort
2025 · Camille Préfontaine, Jasmine Pipella, et al. · Scientific Reports · 6
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Baseline Insulin Secretion Determines Response to Abatacept in Stage 1 Type 1 Diabetes
2025 · Alfonso Galderisi, Alice L.J. Carr, et al. · Diabetes · 4
Stage 1 type 1 diabetes memory B lymphocytes transcriptionally differ from healthy controls and harbor insulin-binding specificities
2025 · Lindsay E Bass, Wyatt J McDonnell, et al. · ImmunoHorizons · 2
Neutrophil-enriched gene signature correlates with teplizumab therapy resistance in different stages of type 1 diabetes
2025 · Gabriele Sassi, Pierre Lemaitre, et al. · Journal of Clinical Investigation · 4
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Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval
2025 · Emily K. Sims, William E. Russell, et al. · Diabetes · 3
Contrasting Adult and Pediatric Populations in a Cohort of At-Risk Relatives in The T1D TrialNet Pathway to Prevention Study
2025 · Erin L. Templeman, Lauric A. Ferrat, et al. · Diabetes Care · 25
Development and recalibration of a multivariable type 1 diabetes prediction model for type 1 diabetes across multiple screening studies
2025 · Erin L. Templeman, Lauric A. Ferrat, et al. · BMC Medicine · 7
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Genetic Risk and Transition Through Preclinical Stages of Type 1 Diabetes
2025 · Andrea K Steck, Hemang M Parikh, et al. · The Journal of Clinical Endocrinology & Metabolism · 5
Prevention of diabetic ketoacidosis in relatives screened for islet autoantibodies and followed up in the TrialNet Pathway to Prevention study at a single institution in Italy
2025 · Sabina Martinenghi, Aurora Merolla, et al. · Diabetologia · 8
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Evaluation of proinsulin(F25D) as a targeting ligand for insulin-binding B cells in autoimmune diabetes
2025 · Kyle D. Apley, Lindsay E. Bass, et al. · Drug Delivery and Translational Research · 4
Type 1 Diabetes TrialNet: Leading the Charge in Disease Prediction, Prevention, and Immunotherapeutic Mechanistic Understanding
2025 · Laura M. Jacobsen, Jamie L. Felton, et al. · Diabetes Care · 19
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M120 Risk Score Improves Identification of Children at High Risk of Developing Clinical Type 1 Diabetes and Reports Short-term Response to Preventive Immunotherapy
2025 · Minh V. Le,, Leonard C. Harrison, et al. · Diabetes Care · 4
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The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes
2025 · Heba M. Ismail, David Cuthbertson, et al. · Diabetes · 6
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Activated polyreactive B cells are clonally expanded in autoantibody positive and patients with recent-onset type 1 diabetes
2025 · Catherine A. Nicholas, Fatima A. Tensun, et al. · Cell Reports · 12
Comparative Analysis of the Sensitivity, Specificity, Concordance, and 5-Year Predictive Power of Diabetes-Related Autoantibody Assays
2025 · Jeffrey P. Krischer, Sarah Muller, et al. · Diabetes · 14
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IA-2A positivity increases risk of progression within and across established stages of type 1 diabetes
2025 · Emily K. Sims, David Cuthbertson, et al. · Diabetologia · 26
Metabolic Phenotype of Stage 1 and Stage 2 Type 1 Diabetes Using Modeling of β Cell Function
2025 · Alfonso Galderisi, Jacopo Bonet, et al. · The Journal of Clinical Endocrinology & Metabolism · 9
A Glucose Fraction Independent of Insulin Secretion: Implications for Type 1 Diabetes Progression in Autoantibody-Positive Cohorts
2025 · Jay M. Sosenko, David Cuthbertson, et al. · Diabetes Technology & Therapeutics · 2
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