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Probing the State of Water on the Surface of Pharmaceutical Salts by X-ray Photoelectron Spectroscopy

Year: 2008

Type: article

Abstract: •The results with both trifluoperazine di-HCl and clonidine HCl provide strong evidence for dissociative adsorption of water on organic hydrochloride salts. •This strongly bound water may act as nuclei for further moisture uptake and cause stability problems for moisture-labile salts. •Future work will investigate: • Role of surface chemistry and defect density of various faces of clonidine HCl single crystals on the extent of dissociation • Comparison between clonidine HCl, clonidine HBr and clonidine free base

Source: Purdue e-Pubs (Purdue University System)

Authors: Pete Guerrieri, Dmitry Zemlyanov, Lynne S. Taylor

Language: English

Topic: Electron and X-Ray Spectroscopy Techniques

Subfield: Surfaces, Coatings and Films

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: AstraZeneca

OpenAlex ID: W1503485276

FWCI:

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