Work

Hypoxia-inducible factor 1 and breast cancer metastasis

Year: 2015

Type: review

Abstract: Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.

Source: Journal of Zhejiang University SCIENCE B

DOI: 10.1631/jzus.b1400221

Authors: Zhao-ji Liu, Gregg L. Semenza, Hua-feng Zhang

Institutions: University of Science and Technology of China, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities, Specialized Research Fund for the Doctoral Program of Higher Education of China