Work

Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors

Year: 2012

Type: article

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/j.bmcl.2012.01.061

Authors: Arun K. Ghosh, Bruno D. Chapsal, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya

Institutions: Purdue University West Lafayette, Georgia State University, Kumamoto University, National Institutes of Health, National Cancer Institute

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministry of Education, Culture, Sports, Science and Technology, Ministry of Health, Labour and Welfare, National Institutes of Health, Japan Society for the Promotion of Science, National Cancer Institute, National Institute of General Medical Sciences

Awards: Elucidation of the Emergence of HIV-1 Variants Resistant to HIV-1 Protease Dimerization Inhibitors (PDIs) and Development of Novel, Potent PDIs, Activity of Resistant Variants of HIV Protease, G5103706978, DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS, The analysis of HIV-protease dimerization mechanism at atomic andmolecular resolution, and the design of novel dimerization inhibition compounds., Design & Synthesis of Nonpeptide Protease Inhibitors, G803258200, Inhibition of Resistant Variants of HIV Protease, Mechanism of spontaneous degradation observed in the insertioncontaining HIV-1 Capsid proteins, G9000082317, G9000252667

OpenAlex ID: W1966835439

FWCI: 1.767

Cites: 21

Cited by: 23

Related to: 10