Angioplasticity in asthma
Year: 2009
Type: review
Abstract: Plasticity of the lung vasculature is intrinsically more complex than other organs due to the presence of two blood supply systems under different arterial pressures, the pulmonary and bronchial arterial systems. The bronchial and pulmonary circulations may both contribute to vascular remodelling in lungs after injury or inflammation. Vascular remodelling in the airway is a long recognized component in asthma. Growing numbers of reports suggest that a pro-angiogenic milieu is not a consequence of, but rather dictates the chronic inflammation of asthma. The fairly recent discovery of EPCs (endothelial progenitor cells) has enabled us to study the bone-marrow-derived cells that regulate lung vascular plasticity in asthma. This mini review provides a concise synopsis of our present knowledge about vascular plasticity in adult lungs, summarizes our current view of angioplasticity in asthma and highlights yet unresolved areas of potential interest.
Source: Biochemical Society Transactions
DOI: 10.1042/bst0370805
Authors: Kewal Asosingh, Serpil C. Erzurum
Institutions: Cleveland Clinic, Cleveland Clinic Research
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1490678758, The Regulation and Role of Nitric Oxide in Asthma, Case Western Reserve University/Cleveland Clinic CTSA (UL1), G231556210, G2343364956, Pathobiology of Asthma, G4206027171, Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*, Nitric Oxide in Pulmonary Hypertension, Extracellular Matrix Synthesis and Turnover in Asthma, G6737073386, Redox Determinants of Severe Asthma, Nitric Oxide in Pulmonary Hypertension, SIGNALING ALLERGIC LUNG DISEASE:NF-KB &T HELPER SUBSETS, GENERAL CLINICAL RESEARCH CENTER, G980506753
OpenAlex ID: W1984614529