Work

New Type II Manumycins Produced by Streptomyces nodosus ssp. asukaensis and Their Biosynthesis.

Year: 2001

Type: article

Abstract: Five new type II manumycins, containing the hydroxyquinol mC7N unit, asukamycins A-II, B-II, C-II, D-II, E-II, were discovered in cultures of Streptomyces nodosus ssp. asukaensis. The biosynthetic origin of the type II manumycins from the type I compounds, containing an epoxyquinol mC7N unit, was deduced from the time course of production and proven by preparing [7'-13C]asukamycin A and demonstrating its incorporation into asukamycin A-II.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.54.340

Authors: YIDING HU, HEINZ G. FLOSS

Institution: University of Washington

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G1287679552, BIOLOGICALLY ACTIVE MICROBIAL METABOLITES