Work

Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071

Year: 2011

Type: article

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/j.bmcl.2011.08.084

Authors: Evan P. Lebois, Gregory J. Digby, Douglas J. Sheffler, Bruce J. Melancon, James C. Tarr, Hyekyung P. Cho, Nicole R. Miller, Ryan Morrison, Thomas M. Bridges, Zixiu Xiang, J. Scott Daniels, Michael R. Wood, P. Jeffrey Conn, Craig W. Lindsley

Institutions: Vanderbilt University, Vanderbilt University Medical Center

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Vanderbilt University, National Institutes of Health, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke

Awards: G1221182432, G1453181953, G2471675597, The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt NCDDDG for Discovery of Novel Treatments for Schizophrenia, M1 and M4 mAChRs in striatum-implication in treatment of movement disorders

OpenAlex ID: W2008702443

FWCI: 1.293

Cites: 37

Cited by: 38

Related to: 10