Work

Endoplasmic reticulum stress in diethylnitrosamine-induced rat liver cancer

Year: 2013

Type: article

Abstract: To analyze the significance of endoplasmic reticulum stress (ERS) in the development of diethylnitrosamine (DEN)-induced liver cancer in rats, critical regulatory factors in ERS signaling pathways were investigated in the present study. The results showed that the expression of ERS-related proteins gradually increased in the early and mid-term stages of carcinogenesis, while in the later stages, the expression of these proteins did not change significantly after reaching a peak. ERS is involved in DEN-induced rat liver injury, the proliferation of liver cells and the occurrence and development of liver cirrhosis. However, ERS did not affect hepatoma cell growth following the formation of rat liver cancer in the current study.

Source: Oncology Letters

DOI: 10.3892/ol.2013.1651

Authors: BIN XIAO, LI-MIN CUI, DONG-JIE MA, SHUANG-PING LIU, XUE-WU ZHANG

Institutions: Yanbian University, Yanbian University Hospital

Language: English

Topic: Endoplasmic Reticulum Stress and Disease

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Natural Science Foundation of China