Work

Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC)

Year: 2009

Type: article

Source: Bioorganic & Medicinal Chemistry

DOI: 10.1016/j.bmc.2009.11.033

Authors: Sharmila Sivendran, Victoria Jones, Dianqing Sun, Yi Wang, Anna E. Grzegorzewicz, Michael S. Scherman, Andrew D. Napper, J. Andrew McCammon, Richard E. Lee, Scott L. Diamond, Michael McNeil

Institutions: University of Pennsylvania, Colorado State University, University of Tennessee Health Science Center, Howard Hughes Medical Institute, University of California San Diego

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Institute on Drug Abuse, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases

Awards: HTS Screen of TB RmlC & RmlD dTDP-Rhamnose Formation Enzymes, Multi-Drug Resistant Tuberculosis Drugs: Targeting Cell Wall Synthetic Enzymes, Penn Center For Molecular Discovery(RMI), G5955884754

OpenAlex ID: W2029235383

FWCI: 1.933

Cites: 23

Cited by: 79

Related to: 10