Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non‐ H odgkin lymphoma subtypes
Year: 2012
Type: article
Study design: Observational Study
Abstract: A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10(-3)). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.
Source: British Journal of Haematology
DOI: 10.1111/bjh.12070
Authors: Susan L. Slager, Nicola J. Camp, Lucia Conde, Tait D. Shanafelt, Sara J. Achenbach, Kari G. Rabe, Neil E. Kay, Anne J. Novak, Timothy G. Call, Paige M. Bracci, Fenna M. C. Sille, Sylvia Sanchez, Nicholas K. Akers, Julie M. Cunningham, Daniel J. Serie, Shannon K. McDonnell, Jose F. Leis, Alice H. Wang, J. Brice Weinberg, Martha Glenn, Brian Link, Celine M. Vachon, Mark C. Lanasa, Christine F. Skibola, James R. Cerhan
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1106065612, G1463712292, G169599190, G1819655924, G1828094709, G2038983678, G2067995313, G2190235346, G2543251811, G2660289629, G2779496123, G2794701286, G2798125399, G3709138859, EPIDEMIOLOGY OF NON-HODGKIN'S LYMPHOMA &RETROVIRAL TEST, G3970052678, EPIDEMIOLOGY OF NON HODGKINS'S LYMPHOMA DATA ANALYSIS, Resequencing and Functional Studies to Identify Causal Gene Variants of Lymphoma, G610676220, Molecular Pathogenesis of Monoclonal B Cell Lymphocytosis and CLL, G6622425196, G7019267552, G715246368, Pooling and expansion of Chronic Lymphocytic Leukemia GWA data, G8866916758, Mayo Clinic Comprehensive Cancer Center Support Grant, Toxic substances in the environment
OpenAlex ID: W2071228097