Work

Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114

Year: 2006

Type: article

Source: Journal of Molecular Biology

DOI: 10.1016/j.jmb.2006.08.007

Authors: Andrey Y. Kovalevsky, Fengling Liu, Sofiya Leshchenko, Arun K. Ghosh, John M. Louis, Robert W. Harrison, Irene T. Weber

Institutions: Georgia State University, Purdue University West Lafayette, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Enzyme Structure and Function

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Energy, National Institutes of Health, National Institute of General Medical Sciences, Fogarty International Center, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Specificity Studies of HIV and HTLV Proteases, Activity of Resistant Variants of HIV Protease, G5103706978, Design & Synthesis of Nonpeptide Protease Inhibitors, G803258200, Inhibition of Resistant Variants of HIV Protease

OpenAlex ID: W2073036247

FWCI: 8.072

Cites: 38

Cited by: 147

Related to: 10