Approaches to the Mitomycins: 4,4a-Secodeiminoquinones
Year: 1978
Type: article
Abstract: Frameworks containing all the stereochemical and functional features except the aziridine and the 4,4a C-N bond of both epimeric series of the mitomycins are prepared in a short synthesis.The mitomycin antibiotics have been the object of many synthetic studies.Recently, a Harvard group has reported the total synthesis of mitomycin A (11, mitomycin C (2), and porfiromycin ( 3 ) .' In addition to the Harvard total synthesis, only two other reports describe successful approaches to the introduction of the la oxygen function of the antibiotics.As a model for the total synthesis program referred to above, a deirninomitomycin was prepared using a variation of a transannular at-4 Mitomycin B."
Source: Heterocycles
Institution: Fordham University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2075543840