Work

Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo.

Year: 1992

Type: article

Abstract: Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N12-formyl derivative of Et 729 and the natural N12-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-beta-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.89.23.11456

Authors: R Sakai, K L Rinehart, Y Guan, A H Wang

Institutions: University of Illinois Urbana-Champaign, University of Illinois System

Language: English

Topic: Synthesis and Biological Activity

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, University of Illinois at Urbana-Champaign, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases