Work

Design, Synthesis, and Biological Evaluation of Truncated Superstolide A

Year: 2013

Type: article

Abstract: By design: A truncated superstolide A, a simplified analogue of the potent anticancer marine macrolide superstolide A, was designed and successfully synthesized by a highly efficient and convergent approach. The biological evaluation showed that this compound maintains the potent anticancer activity of the original natural product superstolide A.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201209300

Authors: Lei Chen, Kausar Begam Riaz Ahmed, Peng Huang, Zhendong Jin

Institutions: University of Iowa, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Synthesis and Biological Activity

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Cancer Institute

Award: Total Synthesis of Anticancer Agents Superstolides A & B