Work

The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H + -ATPase

Year: 2006

Type: review

Abstract: All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in organelle acidification. Not only is the structure of V-ATPases highly conserved among eukaryotes, but there are also many regulatory mechanisms that are similar between fungi and higher eukaryotes. These mechanisms allow cells both to regulate the pHs of different compartments and to respond to changing extracellular conditions. The Saccharomyces cerevisiae V-ATPase has emerged as an important model for V-ATPase structure and function in all eukaryotic cells. This review discusses current knowledge of the structure, function, and regulation of the V-ATPase in S. cerevisiae and also examines the relationship between biosynthesis and transport of V-ATPase and compartment-specific regulation of acidification.

Source: Microbiology and Molecular Biology Reviews

DOI: 10.1128/mmbr.70.1.177-191.2006

Author: Patricia M. Kane

Institution: SUNY Upstate Medical University

Language: English

Topic: ATP Synthase and ATPases Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: A Skpl-containing Complex Regulating V-ATPase Activity, Subunit Structure and Function of Vacuolar H+-ATPases