Work

Structure elucidation of nigricanoside A through enantioselective total synthesis

Year: 2015

Type: article

Abstract: Nigricanoside A was isolated from green alga, and its dimethyl ester was found to display potent cytotoxicity. Its scarcity prevented a full structure elucidation, leaving total synthesis as the only means to determine its relative and absolute stereochemistry and to explore its biological activity. Here we assign the stereochemistry of the natural product through enantioselective total synthesis and provide initial studies of its cytotoxicity.

Source: Chemical Science

DOI: 10.1039/c5sc00281h

Authors: Jie Chen, Panduka Koswatta, J. Robb DeBergh, Peng Fu, Ende Pan, John B. MacMillan, Joseph M. Ready

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Isoquinoline Alkaloid Synthesis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: Welch Foundation, Cancer Prevention and Research Institute of Texas, University of Texas Southwestern Medical Center, National Institutes of Health, National Institute of General Medical Sciences

Awards: G3243684116, G7073091334, Synthesis and Evaluation of Biologically Active Natural Products, G921130799

OpenAlex ID: W2145774945

FWCI: 0.71

Cites: 32

Cited by: 14

Related to: 10